… Allopurinol in plasma was stable at benchtop for 24 h, in … Allopurinol stock standard solutions
were stable for 140 days … samples in pharmacokinetic study of an allopurinol formulation. …

… The primary active metabolite of allopurinol is oxypurinol, which is filtered and partially
reabsorbed in the kidneys. Oxypurinol has the same mechanism of action of allopurinol, but a …

… of allopurinol in patients with renal impairment. These events may be due to increased levels
of serum allopurinol and its active metabolite, oxypurinol… , the allopurinol dosage should be …

In this study, a sustainable HPLC-UV-DAD method was developed and validated for the
determination of allopurinol in tablets and optimization of the dissolution test using factorial …

… active form, oxypurinol. Both allopurinol and oxypurinol inhibit an enzyme called xanthine
oxidase, which is involved in the breakdown of purines to uric acid. Allopurinol has a short half-…

… allopurinol and its active metabolite oxypurinol were determined. RESULTS: Allopurinol and
oxypurinol concentrations were within the therapeutic range in the mother (allopurinol 2 mg/…

… Initiation of allopurinol at first medical contact for acute attacks of gout: A randomized …
Clinical pharmacokinetics and pharmacodynamics of allopurinol and oxypurinol. Clin …

… A simple method for quantification of allopurinol and oxypurinol in human serum by high-performance
liquid chromatography with UV-detection. J Pharm Biomed Anal. 2007; 45(2): 312-…

… Our clinical study found that p.Q141K associated with longer half-life of oxypurinol and
our … Q141K variant allele on the pharmacokinetic parameters of allopurinol and oxypurinol …

… half-life of the active metabolite oxypurinol is much longer at 23 h. Allopurinol is predominately
excreted by the kidneys as its active metabolite oxypurinol [86]. Xanthine oxidoreductase, …