… XO transforms allopurinol into its primary metabolite, oxypurinol. Allopurinol and oxypurinol
share structural similarities with the purine bases HPX and XAN, respectively ( Figure 2 ). …

… allopurinol-associated SCARs demonstrated that oxypurinol … but allopurinol and febuxostat
did not, indicative of oxypurinol… granulysin in response to oxypurinol likely participate in the …

Reactive oxygen species (ROS) have been correlated with almost every human disease. Yet
clinical exploitation of these hypotheses by pharmacological modulation of ROS has been …

… neonates received allopurinol PFI … pharmacokinetic data of allopurinol, oxypurinol,
hypoxanthine, xanthine, and uric acid and to establish if expected target concentrations of allopurinol …

… Oxypurinol Oxypurinol is an active metabolite of allopurinol oxidation and has a stronger
inhibitory … Its drug action and curative effect are similar to those of allopurinol, while the adverse …

… The effects of allopurinol and its downstream metabolite, oxypurinol, on pyrimidine synthesis
include inhibition of orotodine monophosphate decarboxylase (OMD) [51]. The inhibition of …

… Allopurinol is metabolized into the active metabolite oxypurinol primarily by the enzyme …
Allopurinol has a half-life of 1.2 hours, whereas oxypurinol’s half-life is 23 hrs. The active …

… The action pathway of allopurinol is to inhibit the functioning … also converts allopurinol to
its active metabolite oxypurinol (… affects the pharmacokinetics and pharmacodynamics of the …

… is metabolised into oxypurinol and … oxypurinol in wastewater. A total of 180 wastewater
samples collected between 2012 and 2019 were analysed for oxypurinol to estimate allopurinol …