Secreted frizzled related proteins in cardiovascular and metabolic diseases

H Guan, J Zhang, J Luan, H Xu, Z Huang… - Frontiers in …, 2021 - frontiersin.org
… agonists and antagonists, which fine tunes Wnt signaling to … was found in Xenopus laevis,
chicken and zebrafish but not in … SFRP3 was expressed at low levels during development and …

A fibroblast-derived TGFβ/sFRP2 noncanonical Wnt signaling axis underlies epithelial metaplasia in idiopathic pulmonary fibrosis

ML Cohen, AN Brumwell, TC Ho, G Montas, JA Golden… - bioRxiv, 2023 - biorxiv.org
… further test the role of non-canonical Wnt signaling in sFPR2-induced basal gene expression
Cloning and Expression of the Wnt Antagonists Sfrp-2 and Frzb during Chick Development. …

[HTML][HTML] A fibroblast-dependent TGFβ1/sFRP2 noncanonical Wnt signaling axis underlies epithelial metaplasia in idiopathic pulmonary fibrosis

ML Cohen, AN Brumwell, TC Ho, G Montas, JA Golden… - bioRxiv, 2023 - ncbi.nlm.nih.gov
… fibroblast signaling, and promoted by the pleotropic growth factor TGFβ1, itself a key mediator
of … as a Wnt antagonist ( 27 , 28 ), presumably by acting as a decoy for Wnt ligand binding. …

Wingless-type mouse mammary tumor virus integration site regulation of bovine theca cells

LJ Spicer - Journal of Animal Science, 2021 - academic.oup.com
… Endogenous antagonists for WNT signaling exist and include Dickkopf proteins (DKK-1 to
5), … Cloning and expression of the Wnt antagonists Sfrp-2 and Frzb during chick development

Regulation of otic neurosensory specification by Notch and Wnt signalling: insights from RNA-seq screenings in the embryonic chicken inner ear

M Żak, TP Støle, V Plagnol, N Daudet - … in Cell and Developmental …, 2023 - frontiersin.org
… signalling components could contribute to the establishment of the DV gradient of Wnt activity.
Wnt antagonists such as SFRP1, which is expressed in the ventral region of the inner ear (…

The Wnt signaling cascade in the pathogenesis of osteoarthritis and related promising treatment strategies

J Cheng, M Li, R Bai - Frontiers in Physiology, 2022 - frontiersin.org
… the important role of Wnt signaling in bone and joint development, numerous studies have
… Our current understanding of certain endogenous antagonists of the Wnt signaling pathway …

Large intestine embryogenesis: Molecular pathways and related disorders

A Kostouros, I Koliarakis, K Natsis… - International …, 2020 - spandidos-publications.com
antagonist and the subsequent reactivation of Wnt signaling, … Lef-1−/− chicks exhibit stenosis
of the cecal lumen due to the … Wnt8 and only sFRP-2 can block Wnt4 (105), while all Wnt1, 4 …

Single-cell sequencing reveals novel cellular heterogeneity in uterine leiomyomas

J Goad, J Rudolph, M Zandigohar, M Tae… - Human …, 2022 - academic.oup.com
… types within human leiomyomas. Our results will be important for future studies into the origin
and growth … We wanted to investigate whether the MED12-variant affects the WNT signaling …

[PDF][PDF] Wnt secretion and transport in the mammalian nervous system

K Kaiser - is.muni.cz
… the hypothesis of bona fide Wnt antagonist, since it has been … Frzb (a member of SFPR family
of proteins) is able to facilitate … Wnt11 in chick , orientation of PCP components during wing …

Disrupting fzd9b in zebrafish recapitulates stress-and anxiety-like behaviours associated with Williams syndrome

JV Torres-Perez, A Leggieri, A Mech, S Anagianni… - bioRxiv, 2024 - biorxiv.org
Expression of Fzd9 is first detected in neural 123 precursor cells during the development of
… effects reversed by treatment with antagonists of the canonical Wnt signalling 453 pathway. …