[HTML][HTML] Genomics of Trypanosomatidae: where we stand and what needs to be done?

V Yurchenko, A Butenko, AY Kostygov - Pathogens, 2021 - mdpi.com
… Below, we review the current state of genomic research in trypanosomatids with a focus on
… The analysis of gene families and comparative genomic studies discussed above can be …

[HTML][HTML] Genomics and functional genomics in Leishmania and Trypanosoma cruzi: statuses, challenges and perspectives

DC Bartholomeu, SMR Teixeira… - Memórias do Instituto …, 2021 - SciELO Brasil
… The availability of Trypanosomatid genomic data in public … Comparative genomics of
trypanosomatid parasitic protozoa. … Comparative genomic analysis of three Leishmania species …

Ancestral aneuploidy and stable chromosomal duplication resulting in differential genome structure and gene expression control in trypanosomatid parasites

JL Reis-Cunha, SA Pimenta-Carvalho… - Genome …, 2024 - genome.cshlp.org
… Taking advantage of near complete genomes of clades across the trypanosomatids, we
reveal that aneuploidy is widespread throughout these protozoans. Isolate-specific data indicate …

[HTML][HTML] Defeating the trypanosomatid trio: proteomics of the protozoan parasites causing neglected tropical diseases

A Parthasarathy, K Kalesh - RSC Medicinal Chemistry, 2020 - pubs.rsc.org
… are gradually transforming the research landscape of NTDs caused by protozoan parasites.
The Human Genome Project not only created opportunities to treat genetic diseases, but …

[HTML][HTML] Comparative analysis of virulence mechanisms of trypanosomatids pathogenic to humans

AL de Castro Neto, JF Da Silveira… - Frontiers in Cellular and …, 2021 - frontiersin.org
Trypanosomatids are flagellate protozoans that can infect several types of hosts, including
insects and vertebrates from different orders, in their monoxenous and dixenous forms, …

[HTML][HTML] Proteins involved in the biosynthesis of lipophosphoglycan in Leishmania: a comparative genomic and evolutionary analysis

LG Azevedo, ATL de Queiroz, A Barral, LA Santos… - Parasites & vectors, 2020 - Springer
… are protozoan parasites belonging to the family … and metabolism of the parasite changes
drastically. … TriTrypDB along with 22 genomes and proteomes of trypanosomatid species. To …

[HTML][HTML] Shining the spotlight on the neglected: new high-quality genome assemblies as a gateway to understanding the evolution of Trypanosomatidae

ATS Albanaz, M Carrington, AO Frolov, AI Ganyukova… - BMC genomics, 2023 - Springer
… We address several knowledge gaps in trypanosomatid research by undertaking … assembled
genomes for twenty-one trypanosomatid species, with a primary focus on insect parasites

[HTML][HTML] Comparative genomic analyses of new and old world viscerotropic leishmanine parasites: further insights into the origins of visceral leishmaniasis agents

FT Silveira, EC Sousa Junior, RVD Silvestre… - Microorganisms, 2022 - mdpi.com
genomic comparisons among these leishmanine parasites, … in the genome for each
chromosome, and the number of genomic … a high genomic similarity (~99%) among these …

Reductionist pathways for parasitism in euglenozoans? Expanded datasets provide new insights

A Butenko, M Hammond, MC Field, ML Ginger… - Trends in …, 2021 - cell.com
parasitic clade of trypanosomatids (Figure 1A ). Trypanosomatids are, and ancestrally were,
parasites of … DNA (kDNA), the osmotrophic trypanosomatids have likely evolved from a free-…

[HTML][HTML] Genomes of Endotrypanum monterogeii from Panama and Zelonia costaricensis from Brazil: Expansion of Multigene Families in Leishmaniinae Parasites That Are …

PO Tullume-Vergara, KYO Caicedo, JFC Tantalean… - Pathogens, 2023 - mdpi.com
… Herein, we used comparative genomics to identify the … quality assessment of the 27
trypanosomatids genomes used … Takata for cloning and culturing the protozoa used in this …