Transcriptomic analysis of benznidazole-resistant and susceptible Trypanosoma cruzi populations

DA Lima, LO Gonçalves, JL Reis-Cunha… - Parasites & …, 2023 - Springer
protozoan parasitetrypanosomatid genomes using new-generation technologies has
significantly improved our understanding of the underlying metabolic processes in these parasites. …

Detecting sequence variants in clinically important protozoan parasites

L Calarco, J Barratt, J Ellis - International journal for parasitology, 2020 - Elsevier
… This is a concern in developing countries where many pathogenic Protozoa are endemic. …
Limitations in the genome assemblies of protozoans hinder precise comparative genomics

Viruses of protozoan parasites and viral therapy: Is the time now right?

P Barrow, JC Dujardin, N Fasel, AD Greenwood… - Virology journal, 2020 - Springer
… Different species of the trypanosomatid protozoan Leishmania are the causative agents
of cutaneous (CL), visceral (VL) or mucocutaneous (MCL) and disseminated (DCL) …

Systems vaccinology for the design of rational vaccines against protozoan parasites

ML Tomazic, V Marugan-Hernandez, AE Rodriguez - System Vaccinology, 2022 - Elsevier
… State-of-the-art of vaccines in protozoan parasites Apicomplexan and Trypanosomatid
parasites are … Cutting-edge technologies such as comparative genomics or CRISPR/Cas9-based …

A profile of research on the parasitic trypanosomatids and the diseases they cause

D Horn - PLoS neglected tropical diseases, 2022 - journals.plos.org
… The parasitic trypanosomatids cause lethal and debilitating diseases, the leishmaniases,
Chagas disease, and the African trypanosomiases, with major impacts on human and animal …

Phylogenetic framework to explore trait evolution in Trypanosomatidae

AY Kostygov, ATS Albanaz, A Butenko… - Trends in …, 2024 - cell.com
… The number of sequenced trypanosomatid genomes has reached a critical point so that
they are now available for almost all genera and subgenera. Based on this, we inferred a …

… Analysis of Pyruvate-Ferredoxin Oxidoreductase, a Redox Enzyme Involved in the Pharmacological Activation of Nitro-Based Prodrugs in Bacteria and Protozoa

S Duwor, D Brites, P Mäser - Biology, 2024 - mdpi.com
protozoa and bacteria by applying comparative genomics to test … PFOR, such as
trypanosomatid parasites of insects, may … in close proximity with some invading protozoan

Uncovering pseudogenes and intergenic protein-coding sequences in TriTryps' genomes

M Abrahim, E Machado, F Alvarez-Valín… - Genome Biology and …, 2022 - academic.oup.com
… belong to a remarkable group of unicellular, parasitic organisms of the order Kinetoplastida,
genomic-scale data of several trypanosomatids becoming available since 2005 (genomes, …

Comparative genomics of Leishmania donovani progeny from genetic crosses in two sand fly species and impact on the diversity of diagnostic and vaccine …

J Sádlová, M Yeo, DS Mateus, J Phelan… - PLOS Neglected …, 2024 - journals.plos.org
Trypanosomatids were originally considered to be entirely or predominantly clonal. With
the advent of MLST and comparative genomics, evidence of genetic exchange became more …

A New Model Trypanosomatid, Novymonas esmeraldas: Genomic Perception of Its “Candidatus Pandoraea novymonadis” Endosymbiont

A Zakharova, A Saura, A Butenko, L Podešvová… - Mbio, 2021 - Am Soc Microbiol
… The genome annotation yielded 9,299 predicted proteins. These values are comparable
to those from other available trypanosomatid genomes. The genome and annotation …