Real-world management patterns in EGFR-mutant advanced non-small-cell lung cancer before first-line adoption of osimertinib: the REFLECT study in Greece

S Lampaki, G Mountzios, V Georgoulias, A Rapti… - Future …, 2022 - Future Medicine
… Osimertinib was offered as second- and third-line treatment in 69.6 and … 1L therapy used,
due to its increased efficacy compared with the first-generation EGFR-TKIs erlotinib and gefitinib

Third-Line Tyrosine Kinase Inhibitor Therapy Results in 16-Year Remission in a Patient with Stage IV Non-Small-Cell Lung Cancer.

CL Barnhart, DF Christianson - Journal of Hematology …, 2022 - search.ebscohost.com
… from 9% (gefitinib 500-mg daily dose) to 12% (gefitinib 250-mg … Gefitinib was voluntarily
withdrawn from the US market in … 11.9 months in the erlotinib group compared with 9.6 months in …

Lazertinib in pretreated EGFR T790M-mutated advanced non-small cell lung cancer: A real-world multicenter study

H Kim, BC Ahn, J Lee, JB Lee, MH Hong, HR Kim… - Lung Cancer, 2023 - Elsevier
… We aimed to collect real-world data regarding the efficacy … lazertinib as a second- or third-line
therapy. The ORR and DCR … However, our results demonstrate no significant difference

[HTML][HTML] … -TKI plus bevacizumab versus EGFR-TKI monotherapy for patients with EGFR mutation-positive advanced non-small cell lung cancer-A propensity score …

JS Tsai, PL Su, SC Yang, CC Chang, CY Lin… - Journal of the Formosan …, 2021 - Elsevier
… control than erlotinib monotherapy in patients with advanced … and dacomitinib had remarkable
efficacy compared to first-… subsequent second- and third-line therapy was not different …

Prognostic factors affecting survival in third-line treatment of advanced non-small cell lung cancer: Retrospective cohort study

F Aslan, U Demirci, D Kızılgöz, F Yıldız… - Journal of Surgery …, 2020 - dergipark.org.tr
… In the progression after EGFR-TKI, in the second-line treatment, the efficacy of osimertinib
was … second and third-line regimens in an EGFR-wild patient group compared erlotinib with …

Nonsmall cell lung cancer in China

P Chen, Y Liu, Y Wen, C Zhou - Cancer Communications, 2022 - Wiley Online Library
… study (NCT02998528) compared the efficacy of neoadjuvant … patients compared with
comparator EGFR-TKI (gefitinib or erlotinib) … For the third-line therapy of NSCLC, anlotinib has …

[HTML][HTML] PIK3CA mutation as an acquired resistance driver to EGFR-TKIs in non-small cell lung cancer: clinical challenges and opportunities

X Liu, W Mei, P Zhang, C Zeng - Pharmacological Research, 2024 - Elsevier
… - or third-line therapy for advanced non-small-cell lung cancer revealed favorable tolerability.
However, the efficacy … , compared to pemetrexed and cisplatin alone in patients with locally …

Clinical efficacy and safety of maintenance therapy for advanced non-small cell lung cancer: a retrospective real-world study

X Xu, R Li, P Zhu, P Zhang, J Chen, Y Lin… - World Journal of Surgical …, 2021 - Springer
… -line chemotherapy; no other second- or third-line treatments … one received ectinib, erlotinib,
and gefitinib, respectively. … with advanced NSCLC in the real world, we compared the clinical …

… and VEGFR pathways: Results from a pilot study evaluating apatinib plus gefitinib as a first‐line treatment for advanced EGFR‐mutant nonsmall cell lung cancer

Z Zhang, Y Zhang, F Luo, Y Ma, W Fang… - Clinical and …, 2020 - Wiley Online Library
… gene mutation, compared with erlotinib alone. Subsequently, … a third-line monotherapy for
advanced gastric cancer patients, … Combined with PK analysis, safety, and efficacy profile, our …

[HTML][HTML] Efficacy of EGFR-TKIs with or without angiogenesis inhibitors in advanced non-small-cell lung cancer: A systematic review and meta-analysis

Z Chen, J Wei, X Ma, J Yu - Journal of Cancer, 2020 - ncbi.nlm.nih.gov
… controlled trials (RCTs) comparing EGFR-TKIs with and without … A clinical study 12 compared
erlotinib combined with or … alone in second- and third-line treatment due to the blocking of …