… While the efficacy of a gefitinib treatment in … erlotinib is about 5 times longer compared to
the progression observed in clinical trials. Another interesting fact is also a significant difference …

… line PPP and CPC was indirectly compared by synthesizing efficacy and safety data from two
… costs associated with disease management and subsequent third-line therapy, which were …

… Gefitinib was then compared to chemotherapy in three large … phase III studies comparing
erlotinib to chemotherapy. All trials … therapies with first-generation TKIs enhance the efficacy at …

… Non-small cell lung cancer (NSCLC) is the most common … [46] compared dacomitinib to
erlotinib as second- or third-line … higher efficacy in T790M-positive advanced NSCLC in term of …

… Erlotinib, Afatinib, Osimertinib and Pemtrexed chemotherapy … 144 (75%) received first-line
gefitinib or erlotinib (1G-TKI), 47 (… associated with longer PFS compared to T790M-negative (…

… EGFR TKIs have improved efficacy, compared with first-… difference in OS was observed with
afatinib vs gefitinib (27.9 … -line therapy compared with 20.2 months as ≥ third-line therapy (…

… treatments of 0.1 μM gefitinib and 2 μM anlotinib compared … as third-line treatment of locally
advanced or metastatic cases … efficacy in the rechallenge setting after acquired resistance to …

… osimertinib as third-line or beyond treatment. Among the … efficacy, such as erlotinib, gefitinib
and afatinib. Combination … Poziotinib has advantages in size and structure compared to other …

… , compared to other cancers [3]. A major advancement in the … Despite the high efficacy of
EGFR TKIs observed in metastatic EGFRm … The duration of second- or third-line treatment with …

… safety and efficacy of high-dose icotinib in comparison with … noninferior efficacy to gefitinib
as second-/third-line treatment … compared with that reported in trials of erlotinib and gefitinib, …