[HTML][HTML] Comparison of first-generation EGFR-TKIs (gefitinib, erlotinib, and icotinib) as adjuvant therapy in resected NSCLC patients with sensitive EGFR mutations

Q He, J Liu, X Cai, M He, C Li, H Liang… - … Lung Cancer …, 2021 - ncbi.nlm.nih.gov
compared the impact of three first-generation EGFR-TKIs on radical resected early-stage
NSCLC patients harboring EGFR mutations… adjuvant EGFR-TKIs had a better DFS compared to …

[HTML][HTML] … nervous system efficacy among gefitinib, erlotinib and afatinib in patients with epidermal growth factor receptor mutation-positive non-small cell lung cancer

HA Jung, SY Woo, SH Lee, JS Ahn… - … Lung Cancer …, 2020 - ncbi.nlm.nih.gov
… CNS failure compared with gefitinib or erlotinib after adjusting for both EGFR mutation type
and … The second-generation EGFR TKI afatinib has a more potent inhibitory effect (ie, a lower …

Survival benefits from afatinib compared with gefitinib and erlotinib among patients with common EGFR mutation in first‐line setting

WC Kwok, JCM Ho, TCC Tam, MSM Ip… - Thoracic …, 2022 - Wiley Online Library
… of NSCLC patients with EGFR mutations. There are limited reports on comparisons between
… The adverse effects of patients while on first-line EGFR-TKI and osimertinib are summarized …

Cost-effectiveness analysis of first and second-generation EGFR tyrosine kinase inhibitors as first line of treatment for patients with NSCLC harboring EGFR mutations

O Arrieta, R Catalán, S Guzmán-Vazquez, F Barrón… - BMC cancer, 2020 - Springer
… significant differences among adverse effects frequency … erlotinib is dominated by gefitinib
in our cost-effectiveness analysis. Accordingly, any further analysis will only compare gefitinib

The efficacy of first-line tyrosine kinase inhibitors combined with co-medications in Asian patients with EGFR mutation non-small cell lung cancer

VYF Su, KY Yang, TY Huang, CC Hsu, YM Chen… - Scientific reports, 2020 - nature.com
… in patients with advanced NSCLC harboring EGFR mutations compared to gefitinib use. …
analyze the distinct effects of the three TKIs and co-medications use in NSCLC patients with …

… Study Comparing Dacomitinib with Gefitinib as First-Line Treatment in Patients with Advanced Non-Small-Cell Lung Cancer and EGFR-Activating Mutations

TS Mok, Y Cheng, X Zhou, KH Lee, K Nakagawa… - Drugs, 2021 - Springer
compared with gefitinib in patients with EGFR mutation after … EGFR) tyrosine kinase inhibitors
(TKIs) gefitinib and erlotinib … -up and assess the impact of dacomitinib dose reduction on …

[HTML][HTML] Tyrosine kinase inhibitors for the treatment of EGFR mutation-positive non–small-cell lung cancer: a clash of the generations

R Shah, JF Lester - Clinical lung cancer, 2020 - Elsevier
EGFR TKIs developed for NSCLC were erlotinib and gefitinib… in the mechanisms of action
among the different generations. … with EGFR mutation-positive NSCLC, cross-trial comparisons

Efficacy and tolerability of erlotinib 100 mg/d vs. gefitinib 250 mg/d in EGFR-mutated advanced non-small cell lung cancer (E100VG250): an open-label, randomized …

S Zhao, Z Zhang, W Fang, Y Zhang, Z Zhang… - Frontiers in …, 2020 - frontiersin.org
… suggested that erlotinib 25 mg/d led to similar antitumor effect compared with … EGFR mutated
NSCLC, this study showed that erlotinib 100 mg/d had similar DCR compared with gefitinib

Combination of gefitinib and olaparib versus gefitinib alone in EGFR mutant non-small-cell lung cancer (NSCLC): A multicenter, randomized phase II study (GOAL)

…, R Rosell, Spanish Lung Cancer Group - Lung Cancer, 2020 - Elsevier
… of efficacy of gefitinib plus olaparib, compared to gefitinib alone, as … effect would be expressed
as HR (gefitinib compared to … that ARID1A mutations co-existing with EGFR mutations and …

Comparison of gefitinib plus chemotherapy versus gefitinib alone for advanced non-small-cell lung cancer: A meta analysis

M Yi, T He, K Wang, Y Wei - Clinics, 2023 - SciELO Brasil
… TKIs including gefitinib and erlotinib, the second-generation … versus gefitinib alone in patients
with positive EGFR mutation, … by gefitinib enhances the antitumor effect in NSCLC cell lines …