[HTML][HTML] CASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with MYOD and MYOG
Z Liu, X Zhang, H Lei, N Lam, S Carter… - Nature …, 2020 - nature.com
… By comparing CASZ1 and MYOD or MYOG ChIP-seq datasets … define genome wide
CASZ1-binding sites in a cellular differentiation system. We find that genes involved in a myogenic …
CASZ1-binding sites in a cellular differentiation system. We find that genes involved in a myogenic …
[HTML][HTML] BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma
… in this malignancy compared to skeletal muscle and is essential for cell proliferation. …
genome-wide binding for PBRM1 and BRG1 in RH4 cells and analytically defined binding …
genome-wide binding for PBRM1 and BRG1 in RH4 cells and analytically defined binding …
Actin-related protein 5 functions as a novel modulator of MyoD and MyoG in skeletal muscle and in rhabdomyosarcoma
T Morita, K Hayashi - Elife, 2022 - elifesciences.org
… Arp5 in myogenic differentiation of skeletal muscle cells. We … in Arp5- KO cells compared
with parental RD cells (Figure 7B)… a genome- wide ChIP- Seq analysis of MyoD using Arp5- KO …
with parental RD cells (Figure 7B)… a genome- wide ChIP- Seq analysis of MyoD using Arp5- KO …
[HTML][HTML] Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma
S Pomella, P Sreenivas, BE Gryder, L Wang… - Nature …, 2021 - nature.com
… mapped the genome-wide profile of SNAI2 chromatin binding, … and MYOD average signals
compared to SNAI2 and MYOD … could be hindering MYOD from fully binding to key myogenic …
compared to SNAI2 and MYOD … could be hindering MYOD from fully binding to key myogenic …
[HTML][HTML] Genomic and Epigenetic Changes Drive Aberrant Skeletal Muscle Differentiation in Rhabdomyosarcoma
S Pomella, SG Danielli, R Alaggio, WB Breunis… - Cancers, 2023 - mdpi.com
… describe differences in myogenic differentiation characteristics between different groups of
cells … While MYOD1 binds many genes in muscle cells, it modifies gene expression only at a …
cells … While MYOD1 binds many genes in muscle cells, it modifies gene expression only at a …
[HTML][HTML] Biological Role and Clinical Implications of MYOD1L122R Mutation in Rhabdomyosarcoma
D Di Carlo, J Chisholm, A Kelsey, R Alaggio… - Cancers, 2023 - mdpi.com
… myoblasts, RMS typically expresses both MYOD1 and myogenin yet fails to undergo … to
bind myogenic loci more poorly in the RD embryonal RMS cell line compared to primary human …
bind myogenic loci more poorly in the RD embryonal RMS cell line compared to primary human …
FOXF1 is required for the oncogenic properties of PAX3-FOXO1 in rhabdomyosarcoma
… density comparisons between each of the eight FOXF1 binding … , we analyzed the genome-wide
binding of FOXF1 protein to … Disruption of either FOXF1 or MYOD/MYOG binding sites …
binding of FOXF1 protein to … Disruption of either FOXF1 or MYOD/MYOG binding sites …
[PDF][PDF] SIX1 reprograms myogenic transcription factors to maintain the rhabdomyosarcoma undifferentiated state
JY Hsu, EP Danis, S Nance, JH O'Brien, AL Gustafson… - Cell reports, 2022 - cell.com
… reduced genome-wide binding of SIX1 in both SIX1 KD lines compared with Scramble cells
(… By ChIP-seq, we observe that genome-wide SIX1 binding closely overlaps with H3K27ac …
(… By ChIP-seq, we observe that genome-wide SIX1 binding closely overlaps with H3K27ac …
MYBPC2 and MYL1 as significant gene markers for Rhabdomyosarcoma
Z Chen, X Li, P Guo, D Wang - Technology in Cancer …, 2021 - journals.sagepub.com
… Compared with the healthy group, patients with … The MyoD1 and myogenin expression
levels in rhabdomyosarcoma … development of rhabdomyosarcoma by affecting protein binding, …
levels in rhabdomyosarcoma … development of rhabdomyosarcoma by affecting protein binding, …
[PDF][PDF] The 3D chromatin landscape of rhabdomyosarcoma
… between FP and FN cell lines would be salient when comparing across RMS subtypes. To
… , we hypothesized that MYOD, a critical core regulatory factor essential for myogenic cell fate …
… , we hypothesized that MYOD, a critical core regulatory factor essential for myogenic cell fate …