Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases

C Magro, JJ Mulvey, D Berlin, G Nuovo… - Translational …, 2020 - Elsevier
… of complement activation and microvascular thrombosis in … a catastrophic, complement-mediated
thrombotic microvascular … Potential mechanisms of complement activation, including …

[HTML][HTML] Is the COVID‐19 thrombotic catastrophe complement‐connected?

EM Conway, ELG Pryzdial - Journal of Thrombosis and Haemostasis, 2020 - Elsevier
… therapies that are highly effective in protecting against thrombosis in aHUS, could be …
evidence for complement participating in the pathophysiology underlying the thrombotic diathesis …

[HTML][HTML] Complement C5a induces the generation of neutrophil extracellular traps by inhibiting mitochondrial STAT3 to promote the development of arterial thrombosis

Y Chen, X Li, X Lin, H Liang, X Liu, X Zhang… - Thrombosis …, 2022 - Springer
… In this study, we demonstrated that complement C5a induced the … thrombosis in a FeCl 3
-induced arterial thrombosis model in C57BL/6 mice. Hence, our study identifies complement

[HTML][HTML] Inflammation in cerebral venous thrombosis

J Ding, B Song, X Xie, X Li, Z Chen, Z Wang… - Frontiers in …, 2022 - frontiersin.org
inflammatory process in venous thrombus formation, regarded as a double-edged sword
during thrombosis… Additionally, a growing body of proinflammatory factors such as complements

[HTML][HTML] Is COVID-19 associated thrombosis caused by overactivation of the complement cascade? A literature review

A Fletcher-Sandersjöö, BM Bellander - Thrombosis research, 2020 - Elsevier
complement cascade? In this review, we summarize the literature on thrombotic complications
in COVID-19, complement … crosstalk between the complement and coagulation systems. …

Inflammation and thrombosis in COVID-19 pathophysiology: proteinase-activated and purinergic receptors as drivers and candidate therapeutic targets

K Sriram, PA Insel - Physiological reviews, 2021 - journals.physiology.org
… on inflammatory and other cells promotes complement activation … complement component
occurs and increases with tissue injury and inflammation by properdin and other inflammatory

Complement and the prothrombotic state

CQ Schmidt, H Schrezenmeier… - Blood, The Journal of …, 2022 - ashpublications.org
… the disease complement hyperactivation, angiopathic thrombosis, … of thrombosis, complement
activation, and potential … the overlap between thrombosis and complement is also strongly …

[HTML][HTML] Coagulopathy, endothelial dysfunction, thrombotic microangiopathy and complement activation: potential role of complement system inhibition in COVID-19

X Wang, KK Sahu, J Cerny - Journal of thrombosis and thrombolysis, 2021 - Springer
… a local complement activation and inflammatory response. … or dysregulation of the complement
cascade, which could cause … Similar activation of complement cascade has been noted in …

[HTML][HTML] Immunity, endothelial injury and complement-induced coagulopathy in COVID-19

L Perico, A Benigni, F Casiraghi, LFP Ng… - Nature Reviews …, 2021 - nature.com
… In severe cases of COVID-19, massive endothelial dysfunction, widespread coagulopathy
and complement-induced thrombosis can lead to the development of systemic …

[HTML][HTML] Complement factor D as a strategic target for regulating the alternative complement pathway

J Barratt, I Weitz - Frontiers in immunology, 2021 - frontiersin.org
… , excessive complement activation and/or the loss of complementinflammation, and
thrombosis. One of the three pathways of the complement system, the alternative complement