… in thrombo‐inflammatory diseases … thrombosis, inflammation, and tissue damage. However,
recent studies have shown that these interactions also regulate the resolution of inflammation…

… of cardiac thrombi can promote platelet aggregation (95). Interestingly, an increase of
complement C5a in the plasma of STEMI patients was recently connected to thrombus formation. …

Hemostasis, thrombosis, and inflammation are tightly interconnected processes which may
give rise to thrombo-inflammation, involved in infectious and non-infectious acute and …

… activation of platelets, leukocytes, endothelial cells, and complement [69]. The causal role of
CRP … vWF is another crucial mediator in the interaction of inflammation with thrombosis. The …

… Another recent study provided evidence for complement activation in thrombotic APS as
well as … activated complement directly and contributed to thrombosis whereas mutations in …

… by the interactions between hyperactive coagulation and complement systems – induced
by hyper-inflammatory conditions, resulting in a pro-thrombotic state and diffuse tissue injury. …

… complements… complement system was found to participate in a wide range of physiological
and pathophysiological conditions. Inflammatory disturbance, organ development, thrombotic …

… clot formation when injected into a murine model of thrombosis [13]. Accordingly, the … -19-associated
thrombosis in whom tissue analysis revealed direct viral-induced and complement-…

… Upon activation, A1 astrocytes increase the expression of numerous genes of the classic
complement cascade and inflammatory factors that communicate with M1 microglia and …

… of an early inflammatory phenotype driven by complement and coagulation pathway-related
mechanisms [10, 59, 60]. This enhanced inflammatory-complement and coagulant tone …