[HTML][HTML] Platelets as mediators of neuroinflammation and thrombosis

E Rawish, H Nording, T Münte, HF Langer - Frontiers in immunology, 2020 - frontiersin.org
thrombosis and inflammation, … inflammatory and thrombotic responses, which has recently
been reviewed elsewhere (38). Moreover, a crosstalk between platelets and the complement

[HTML][HTML] Thrombo-inflammation in cardiovascular disease: an expert consensus document from the Third Maastricht Consensus Conference on Thrombosis

E d'Alessandro, C Becker, W Bergmeier… - Thrombosis and …, 2020 - thieme-connect.com
Thrombo-inflammation describes the complex interplay between blood coagulation and
inflammation that plays a critical role in cardiovascular diseases. The third Maastricht …

Analysis of complement deposition and viral RNA in placentas of COVID-19 patients

JJ Mulvey, CM Magro, LX Ma, GJ Nuovo… - Annals of diagnostic …, 2020 - Elsevier
… Vascular complement deposition in the … thrombosis without complement deposition may
reflect the systemic nature of COVID-19's procoagulant effects unrelated to systemic complement

[HTML][HTML] Platelet FcγRIIA in immunity and thrombosis: adaptive immunothrombosis

P Patel, JV Michael, UP Naik, SE McKenzie - Journal of Thrombosis and …, 2021 - Elsevier
… immune response induced by the formation of thrombi inside blood vessels, in … thrombotic
disorders. By virtue of their receptors for various classes of immunoglobulins and complement

The emerging threat of (micro) thrombosis in COVID-19 and its therapeutic implications

JD McFadyen, H Stevens, K Peter - Circulation research, 2020 - Am Heart Assoc
complement activation and the production of inflammatorythrombus formation in animal
models of thrombosis without … animal models of systemic inflammatory response syndrome, …

Thrombosis in COVID‐19

TC Hanff, AM Mohareb, J Giri, JB Cohen… - American journal of …, 2020 - Wiley Online Library
Complement activation is robust in sepsis, and inhibition of the complement system can …
microvascular injury accompanied by terminal components of complement activation: C5b-9, …

Microvascular thrombosis: experimental and clinical implications

MA Bray, SE Sartain, J Gollamudi, RE Rumbaut - Translational Research, 2020 - Elsevier
… these enzymes in regulation of thrombotic tone in endothelial cells: endothelial cell COX-1
and COX-2 both prevent thrombosis, albeit via distinct and complementary pathways. From a …

Neurovascular injury with complement activation and inflammation in COVID-19

MH Lee, DP Perl, J Steiner, N Pasternack, W Li… - Brain, 2022 - academic.oup.com
The underlying mechanisms by which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
leads to acute and long-term neurological manifestations remains obscure. We …

Severe COVID‐19 infection and thrombotic microangiopathy: success does not come easily.

E Gavriilaki, RA Brodsky - British journal of haematology, 2020 - search.ebscohost.com
… hit are pregnancy, inflammation, surgery or autoimmunity.The complement system is part of
the … Except for inflammation, a link also exists between the complement system and platelet …

Pharmacological approach for the reduction of inflammatory and prothrombotic hyperactive state in COVID-19 positive patients by acting on complement cascade

A Vitiello, R La Porta, V D'Aiuto, F Ferrara - Human Immunology, 2021 - Elsevier
… terminal complement pathway blockade represents a potential therapeutic option to reduce
the inflammatory state and the risk of thrombosis … with unregulated complement proteins and …