… these enzymes in regulation of thrombotic tone in endothelial cells: endothelial cell COX-1
and COX-2 both prevent thrombosis, albeit via distinct and complementary pathways. From a …

… It has been reported that the terminal complement complex may induce a pro-thrombotic
and pro-inflammatory endothelium phenotype and mediate vWF release not necessarily as a …

… This article is part of a themed issue on Canonical and non‐canonical functions of the
complement system in health and disease. To view the other articles in this section visit http://…

… Studies have also suggested that signs and symptoms of severe COVID-19 infection
resembled the phenotype of complement-mediated thrombotic microangiopathies (TMA), rather …

… may initiate inflammation and thrombosis. NETs together with the complement system
were … , leading to the amplification loop of complement and neutrophil activation and further …

… Complement C3 binds fibrinogen and compromises fibrin clot lysis, thereby enhancing the
risk of thrombosis… as a novel therapeutic target to reduce thrombosis risk by analyzing: (i) …

… a systemic microvascular thrombosis in the context of complement activation and a persistent
inflammatory state [4]. Increasing D-dimers and high levels of pro-inflammatory cytokines, …

… disruption and vascular thrombosis in histopathologic … of macrophage, complement, platelet
activation, thrombosis, and … interactions between inflammatory and thrombosis pathways …

… activation independently of Ab and to promote biological effects associated with complement…
the classical complement pathway, which in turn stimulates coagulation leading to thrombus …

… Deregulated complement activation may fuel cytokine-driven hyper-inflammation, thrombotic
… Complement therapeutics have gained traction as candidate drugs for countering the …