Complement activation in the disease course of coronavirus disease 2019 and its effects on clinical outcomes

AH de Nooijer, I Grondman… - The Journal of …, 2021 - academic.oup.com
complement system has a potent inflammatory effect, we assessed the relationship between
inflammatory and complement … of these 2 systems (inflammatory and complement) but also …

[HTML][HTML] Endothelial cell phenotype, a major determinant of venous thrombo-inflammation

M Pilard, EL Ollivier, V Gourdou-Latyszenok… - Frontiers in …, 2022 - frontiersin.org
… to the interactions between inflammation and thrombosis in cardiovascular diseases with a
… Together with the complement system, platelets and endothelial cells induce NET formation …

The complement system

RJ Johnson - Biomaterials science, 2020 - Elsevier
… but not resting platelets and facilitates complement activation on the platelet surface providing
a mechanism for local complement activation at sites of thrombosis. Using purified and gel-…

[HTML][HTML] SARS-CoV-2 antibodies mediate complement and cellular driven inflammation

I Jarlhelt, SK Nielsen, CXH Jahn, CB Hansen… - Frontiers in …, 2021 - frontiersin.org
… -inflammatory cytokine TNF-α. Our results indicate that SARS-CoV-2 antibodies might drive
significant inflammatory responses through the classical complement … classical complement

Complement activation in human sepsis is related to sepsis-induced disseminated intravascular coagulation

T Abe, K Kubo, S Izumoto, S Shimazu, A Goan… - Shock, 2020 - journals.lww.com
… The final product of complement activation, the C5b-9 complex, attacks the pathogen by …
complement activation caused by dysregulation causes several diseases, such as thrombotic

Targeting complement activation in COVID-19

HS Kulkarni, JP Atkinson - Blood, The Journal of the American …, 2020 - ashpublications.org
Complement activation occurs in critically ill patients with SARS-CoV-2 infection and likely
contributes to end-organ failure. A role for the complement … in thrombotic microangiopathies: …

Harnessing adenosine A2A receptors as a strategy for suppressing the lung inflammation and thrombotic complications of COVID-19: Potential of pentoxifylline and …

JJ DiNicolantonio, J Barroso-Aranda - Medical hypotheses, 2020 - Elsevier
inflammatory and anti-thrombotic effects that potentially could be highly protective in this regard.
The venerable drug pentoxifylline (PTX) exerts both anti-inflammatorycomplementary to …

[HTML][HTML] The youngbloods. Get together. Hypercoagulation, complement, and NET formation in HIV/SIV pathogenesis

TA Reno, L Tarnus, R Tracy, AL Landay, I Sereti… - Frontiers in …, 2022 - frontiersin.org
… infection, persistent inflammation can also trigger thrombosis and may … thrombosis, pulmonary
embolism, myocardial infarction, or stroke. Contributing to the increased risk of thrombosis

Thrombosis and Coagulopathy in COVID-19

JE Gomez-Mesa, S Galindo-Coral, MC Montes… - Current problems in …, 2021 - Elsevier
… oxygen pressure/inspired fraction of O2 (PaO2/FiO2) by mitigating the formation of microthrombi
and associated pulmonary coagulopathy, also decreasing complementary inflammation. …

Mechanisms of SARS-CoV-2-induced lung vascular disease: potential role of complement

KR Stenmark, MG Frid… - Pulmonary …, 2021 - journals.sagepub.com
… /chemokines, dynamically recruit and activate inflammatory cells and platelets, and
centrally participate in pro-thrombotic processes (thrombotic microangiopathies). Initial reports …