[HTML][HTML] MEF2C opposes Notch in lymphoid lineage decision and drives leukemia in the thymus
… T cell differentiation in established early thymocyte stages, we then transduced early CD7
+ … The sequences of the complementary MEF2C shRNA oligos with Acc65I and EcoRI …
+ … The sequences of the complementary MEF2C shRNA oligos with Acc65I and EcoRI …
[PDF][PDF] C/EBPβ-induced lymphoid-to-myeloid transdifferentiation emulates granulocyte-monocyte progenitor biology
LT Nguyen, K Zimmermann, E Kowenz-Leutz, R Lim… - Stem Cell Reports, 2024 - cell.com
… of myelomonopoietic differentiation states that seamlessly fit into … 7 and 8 mainly expressed
B lymphoid-specific genes (Ebf1, … The v-Abl oncoprotein complements the CSF2 dependency …
B lymphoid-specific genes (Ebf1, … The v-Abl oncoprotein complements the CSF2 dependency …
Phenotypic and genotypic infidelity in B-lineage neoplasms, including transdifferentiation following targeted therapy: Report from the 2021 SH/EAHP Workshop
… the tightly regulated division and differentiation … to differentiate into alternative cell types,
become committed to a single line of differentiation, and ultimately end up in a fully differentiated …
become committed to a single line of differentiation, and ultimately end up in a fully differentiated …
The emerging roles of histone demethylases in cancers
D Tong, Y Tang, P Zhong - Cancer and Metastasis Reviews, 2024 - Springer
Modulation of histone methylation status is regarded as an important mechanism of epigenetic
regulation and has substantial clinical potential for the therapy of diseases, including …
regulation and has substantial clinical potential for the therapy of diseases, including …
[HTML][HTML] MYC's fine line between B cell development and malignancy
O de Barrios, A Meler, M Parra - Cells, 2020 - mdpi.com
… The inhibition of erythroid differentiation was the first evidence of MYC activity in vitro, …
a complementary function but also is essential for ensuring leukemic transformation [43,45]. …
a complementary function but also is essential for ensuring leukemic transformation [43,45]. …
[HTML][HTML] Metabolic requirements of Th17 cells and of B cells: Regulation and defects in health and in inflammatory diseases
J Bystrom, TE Taher, SM Henson, DJ Gould… - Frontiers in …, 2022 - frontiersin.org
… and complementary roles in protecting from infections and cancer. Gene rearrangements in
… IL-10 production by MZ precursor B cells has been shown to regulate the differentiation of …
… IL-10 production by MZ precursor B cells has been shown to regulate the differentiation of …
[HTML][HTML] Marginal zone B-cell populations and their regulatory potential in the context of HIV and other chronic inflammatory conditions
K Doyon-Laliberté, M Aranguren, J Poudrier… - International Journal of …, 2022 - mdpi.com
… However, the B lymphoid progenitor compartment differs … for the expression of genes involved
in FO differentiation [20]. It … via the complement system through complement receptors such …
in FO differentiation [20]. It … via the complement system through complement receptors such …
Alternative splicing of its 5′-UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies
… B-cell differentiation and B-lymphoid malignancies, … (Complement Technology) was added
at 20% concentration (volume-to-volume ratio) as a source of complement, for complement-…
at 20% concentration (volume-to-volume ratio) as a source of complement, for complement-…
Tumor Evolution through Differentiation in B-Cell Lymphomas
D Fitzgerald - 2024 - archiv.ub.uni-heidelberg.de
Since the dawn of multicellular life, cells have diversified through the differentiation of …
differentiation. In this thesis, I challenged this view by investigating whether cell-type differentiation …
differentiation. In this thesis, I challenged this view by investigating whether cell-type differentiation …
Cancer as a Disease of Development Gone Awry
BZ Stanger, GM Wahl - … Review of Pathology: Mechanisms of …, 2024 - annualreviews.org
… , where cellular growth, differentiation, motility, and intercellular cross talk … This created a
paradigm for the complementary approaches … Involvement of the Blymphoid system in chronic …
paradigm for the complementary approaches … Involvement of the Blymphoid system in chronic …