… ), BLK (which encodes the B lymphoid tyrosine kinase) and … subset of genes enriched for
regulation of differentiation and … GRNs and the associated complement of surface proteins in …

… Transcriptional analyses revealed that IRF4 was critical for inducing MYC target genes and
metabolic gene sets during the earliest cell divisions. Complementary chromatin accessibility …

… Pathogenic variants in NOTCH1 and NOTCH2 genes frequently arise in cHL. Mutations in
genes associated with epigenetic regulation (CREBBP and EP300) are particularly frequent in …

… observed in differentiated cells (~ 60%) are established at early developmental stages and
accumulate as development progresses. HMRs that arise during differentiation frequently (~ …

Hematopoiesis, or the production of all blood cells from a rare population of hematopoietic
stem cells (HSCs), is a tightly regulated process that replenishes our blood and immune …

… repair and remodelling of the immunoglobulin gene locus architecture. Here, we review the
molecular events required for CSR, the mechanisms involved in regulating these events and …

… (eg epigenetics factors) and how they control differentiation, … of specific sets of genes
through various mechanisms. These … , PAX5 is expressed exclusively in B lymphoid cells (23), …

… osteoclast differentiation and function has significantly … It was originally derived from mice
skin complementary DNA. … B-lymphoid lineage cells may affect the pathophysiology of bone …

… /EBPα contributes to early B lymphoid development. The murine Cebpa gene contains a 450
… (CLP) population, with 4-fold fewer B-lymphoid colonies forming in cultures with IL-7, 2-fold …

… These needs have driven the adoption of multiple complementary single-cell sequencing …
heterogeneity that underpins ALL gene expression, cellular differentiation, and clonal …