Regulation of Expression and Latency in BLV and HTLV

A Pluta, JP Jaworski, RN Douville - Viruses, 2020 - mdpi.com
… However, the cell type and its differentiation state with respect … early stages of viral
expression [95]. In addition, the U3 region of the BLV LTR includes B-lymphoid-specific cis-regulatory

[PDF][PDF] Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis

D Wang, M Tanaka-Yano, E Meader, MA Kinney… - Cell reports, 2022 - cell.com
… Our results add to these observations in that we find that not only does Lin28 implement
juvenile B-lymphoid differentiation states but it also controls juvenile lymphoid-biased …

Significance of intratumoral infiltration of B cells in cancer immunotherapy: From a single cell perspective

S Gu, L Qian, Y Zhang, K Chen, Y Li, J Wang… - Biochimica et Biophysica …, 2021 - Elsevier
… may facilitate a better understand of their mechanisms [25]. From a … , differentiation trajectory,
and interactions with other cells, and summarize the mechanisms by which B cells regulate

Metabolic gatekeepers of pathological B cell activation

T Sadras, LN Chan, G Xiao… - … Pathology: Mechanisms …, 2021 - annualreviews.org
… In this review, we discuss mechanisms that we term metabolic gatekeepers to eliminate
pathogenic B cell clones on the basis of energy depletion. Chronic activation signals from …

Oncogene-induced reprogramming in acute lymphoblastic leukemia: towards targeted therapy of leukemia-initiating cells

V Fregona, M Bayet, B Gerby - Cancers, 2021 - mdpi.com
… their regulatory signaling pathways during early differentiation … Later in life, the acquisition
of full complement mutations … , and leads to the genetic heterogeneity of the tumor bulk at the …

Contribution of adaptive immunity to human COPD and experimental models of emphysema

F Kheradmand, Y Zhang, DB Corry - Physiological reviews, 2023 - journals.physiology.org
… tertiary T- and B-lymphoid aggregates in emphysematous … to activate Th2 and Th17
differentiation, leading to immune … cascade, the first component of the classical complement

Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing

K Li, Y Liu, H Cao, Y Zhang, Z Gu, X Liu, A Yu… - Nature …, 2020 - nature.com
… of developmental enhancers during hematopoietic lineage differentiation. Hence, the
enhancer-targeting CRISPR epigenetic editing systems provide opportunities for functional …

Antigen loss after targeted immunotherapy in hematological malignancies

T Zhou, HW Wang - Clinics in laboratory medicine, 2021 - labmed.theclinics.com
… immune system, including complement-dependent cytotoxicity, … , either by activating the
complement system or by recruiting Fc … It was first recognized as a differentiation and activation …

Single Cell Transcriptomics to Understand HSC Heterogeneity and Its Evolution upon Aging

L Hérault, M Poplineau, E Remy, E Duprez - Cells, 2022 - mdpi.com
… our understanding of HSC differentiation potential. They confirmed the early priming of HSCs
to … from single cell data and complement prior knowledge of gene regulatory network of the …

[PDF][PDF] Lin28b regulation of early-life B lymphopoiesis. A model system to study how self-reactive B cells develop in early life.

H Åkerstrand - 2023 - portal.research.lu.se
… that exerts post-transcriptional gene regulation. The exact LIN28B mechanism in B cell …
To identify the underlying mechanism, we explored the LIN28B mRNA interactome in B cell …