[HTML][HTML] Mechanisms underpinning poor antibody responses to vaccines in ageing

J Le Lee, MA Linterman - Immunology letters, 2022 - Elsevier
… and diversification of their antibody genes, before differentiating into long-lived antibody-…
Such cell-mediated immunity has been shown to complement antibody-mediated protection …

[HTML][HTML] Gene transactivation and transrepression in myc-driven cancers

M Scafuro, L Capasso, V Carafa, L Altucci… - International journal of …, 2021 - mdpi.com
… these two genes affect complementary targets and regulate their activities … genetic and
epigenetic checkpoint mechanisms which control cell proliferation, apoptosis, and differentiation

[HTML][HTML] Latest perspectives on glucocorticoid-induced apoptosis and resistance in lymphoid malignancies

D Clarisse, F Offner, K De Bosscher - … et Biophysica Acta (BBA)-Reviews on …, 2020 - Elsevier
… analyzing the plethora of proposed mechanisms and highlighting therapeutic opportunities
that emerge from these studies. In conclusion, early detection of glucocorticoid resistance in …

Functional definition of a transcription factor hierarchy regulating T cell lineage commitment

L Garcia-Perez, F Famili, M Cordes, M Brugman… - Science …, 2020 - science.org
… Therefore, we examined the role of Tcf1 at the earliest stages … —and functionally
complementary—target genes, Gata3 and … to better investigate the differentiation capacity of Tcf1 …

MNDA, a PYHIN factor involved in transcriptional regulation and apoptosis control in leukocytes

S Bottardi, T Layne, AC Ramòn, N Quansah… - Frontiers in …, 2024 - frontiersin.org
… PYHIN factor myeloid nuclear differentiation antigen (MNDA) … could also explain why it can
complement the effect of viral … CD19 + /CD5 + B lymphoid cells, detected in peripheral blood …

Innate Lymphoid Cells in Bladder Cancer: From Mechanisms of Action to Immune Therapies

ODV Noel, Z Hassouneh, RS Svatek… - Cancer Immunology …, 2024 - AACR
first identified members of the ILC family, initially discovered in the 1970s as non-T and non-B
lymphoid … mediates ILC2-favored differentiation while repressing differentiation of T cells (…

CXCR4 Regulates B Cell Receptor Editing

MK Okoreeh - 2020 - search.proquest.com
mechanism of receptor editing that lead to the usage of the λ-chain remain ill defined. Herein,
we elucidate transcriptional and epigenetic … been acquired by partial differentiation into the …

[HTML][HTML] Microenvironment remodeling and subsequent clinical implications in diffuse large B-cell histologic variant of Richter syndrome

H Auge, AB Notarantonio, R Morizot… - Frontiers in …, 2020 - frontiersin.org
… This immune checkpoint inhibitor is also described in B lymphoid malignancies, particularly
… does not engage Fc receptors or activate complement. Nivolumab and Pembrolizumab block …

[HTML][HTML] Non-coding RNAs as mediators of epigenetic changes in malignancies

S Kumar, EA Gonzalez, P Rameshwar, JP Etchegaray - Cancers, 2020 - mdpi.com
… either binds with perfect or imperfect complementarity to the mRNA target, … the B-lymphoid
cells, while miR-17, miR-24a and miR-155 are linked to early stages of myeloid differentiation […

The fetal-to-adult hematopoietic stem cell transition and its role in childhood hematopoietic malignancies

R Mack, L Zhang, P Breslin, SJ, J Zhang - Stem cell reviews and reports, 2021 - Springer
differentiation potential but lack megakaryocytic and erythroid potential. LMPs have been
proposed to be the first … features of the epigenetic and transcriptional regulatory landscape with …