LncRNAs in blood cells: Roles in cell development and potential pathogenesis in hematological malignancies

X Guan, Y Sun, C Zhang - Critical Reviews in Oncology/Hematology, 2022 - Elsevier
… , epigenetic regulation, and cell differentiation regulation. In … other LncRNAs through
complementary sites thus regulating … (BSAP) was only expressed in B-lymphoid lineage within the …

Exploring mechanisms of T-cell acute lymphoblastic leukemia pathogenesis through molecular characterization of normal T-cell development

AR Wong - 2022 - open.library.ubc.ca
… is to gain a greater understanding of the molecular events during early human T-cell
differentiation to allow for dissection of particular genetic events that may occur in T-ALL. This was …

The dark side of stemness–the role of hematopoietic stem cells in development of blood malignancies

J Filipek-Gorzała, P Kwiecińska, A Szade… - Frontiers in …, 2024 - frontiersin.org
… of secondary genetic lesions is necessary to complement the … cells are likely committed to
the B-lymphoid lineage (202). … epigenetic factors, which regulate multilineage differentiation

Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia

RJ Autry, SW Paugh, R Carter, L Shi, J Liu… - Nature cancer, 2020 - nature.com
… Although there are several known genetic and epigenetic mechanisms of glucocorticoid …
multiple forms of genomic and epigenetic variants to identify mechanisms of drug resistance in …

[HTML][HTML] Forward and reverse genetics of b cell malignancies: from insertional mutagenesis to crispr-cas

JC Dawes, AG Uren - Frontiers in Immunology, 2021 - frontiersin.org
genetic strategies in mice can provide complementarydifferentiation, migration, rearrangement
of immunoglobulin … of mice having DLBCL like B lymphoid malignancies. These had …

[PDF][PDF] Mechanisms of action and vulnerabilities associated with the oncogene EZH2 in germinal centre B-cell non-Hodgkin lymphoma

J Nolan - 2023 - tara.tcd.ie
… to gain new insight into the mechanism of action of the oncogene … Chromatin modifying
gene mutations in B-lymphoiddifferentiation genes and derepression of aberrantly repressed …

H3K27me3 demethylase UTX restrains plasma cell formation

AK Kania, MJ Price, LE George-Alexander… - The Journal of …, 2022 - journals.aai.org
… apoptosis, which correlated with enrichment of H3K27me3 at proapoptotic genes. Collectively,
this study places UTX as an epigenetic factor restraining B cell differentiation into PCs. …

MLLT3 Isoforms Regulate Hematopoietic Stem Cell Maturation and Fate Decisions

A Vavilina-Halstead - 2024 - escholarship.org
… , suggesting distinct but complementary roles for the two … differentiation is unable to establish
the mechanisms needed … -HSPCs led to upregulation of B lymphoid genes (IL7R, EBF1…

Single cell dissection of developmental origins and transcriptional heterogeneity in B-cell acute lymphoblastic leukemia

I Iacobucci, AGX Zeng, Q Gao, L Garcia-Prat… - bioRxiv, 2023 - biorxiv.org
… Single cell characterization of B-lymphoid differentiation and leukemic cell states during
chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable …

[HTML][HTML] Transcription factor TFII-I fine tunes innate properties of B lymphocytes

A Singh, M Kaileh, S De, K Mazan-Mamczarz… - Frontiers in …, 2023 - frontiersin.org
The ubiquitously expressed transcription factor TFII-I is a multifunctional protein with pleiotropic
roles in gene regulation. TFII-I associated polymorphisms are implicated in Sjögren’s …