LncRNAs in blood cells: Roles in cell development and potential pathogenesis in hematological malignancies
X Guan, Y Sun, C Zhang - Critical Reviews in Oncology/Hematology, 2022 - Elsevier
… , epigenetic regulation, and cell differentiation regulation. In … other LncRNAs through
complementary sites thus regulating … (BSAP) was only expressed in B-lymphoid lineage within the …
complementary sites thus regulating … (BSAP) was only expressed in B-lymphoid lineage within the …
Exploring mechanisms of T-cell acute lymphoblastic leukemia pathogenesis through molecular characterization of normal T-cell development
AR Wong - 2022 - open.library.ubc.ca
… is to gain a greater understanding of the molecular events during early human T-cell
differentiation to allow for dissection of particular genetic events that may occur in T-ALL. This was …
differentiation to allow for dissection of particular genetic events that may occur in T-ALL. This was …
The dark side of stemness–the role of hematopoietic stem cells in development of blood malignancies
J Filipek-Gorzała, P Kwiecińska, A Szade… - Frontiers in …, 2024 - frontiersin.org
… of secondary genetic lesions is necessary to complement the … cells are likely committed to
the B-lymphoid lineage (202). … epigenetic factors, which regulate multilineage differentiation…
the B-lymphoid lineage (202). … epigenetic factors, which regulate multilineage differentiation…
Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia
… Although there are several known genetic and epigenetic mechanisms of glucocorticoid …
multiple forms of genomic and epigenetic variants to identify mechanisms of drug resistance in …
multiple forms of genomic and epigenetic variants to identify mechanisms of drug resistance in …
[HTML][HTML] Forward and reverse genetics of b cell malignancies: from insertional mutagenesis to crispr-cas
JC Dawes, AG Uren - Frontiers in Immunology, 2021 - frontiersin.org
… genetic strategies in mice can provide complementary … differentiation, migration, rearrangement
of immunoglobulin … of mice having DLBCL like B lymphoid malignancies. These had …
of immunoglobulin … of mice having DLBCL like B lymphoid malignancies. These had …
[PDF][PDF] Mechanisms of action and vulnerabilities associated with the oncogene EZH2 in germinal centre B-cell non-Hodgkin lymphoma
J Nolan - 2023 - tara.tcd.ie
… to gain new insight into the mechanism of action of the oncogene … Chromatin modifying
gene mutations in B-lymphoid … differentiation genes and derepression of aberrantly repressed …
gene mutations in B-lymphoid … differentiation genes and derepression of aberrantly repressed …
H3K27me3 demethylase UTX restrains plasma cell formation
… apoptosis, which correlated with enrichment of H3K27me3 at proapoptotic genes. Collectively,
this study places UTX as an epigenetic factor restraining B cell differentiation into PCs. …
this study places UTX as an epigenetic factor restraining B cell differentiation into PCs. …
MLLT3 Isoforms Regulate Hematopoietic Stem Cell Maturation and Fate Decisions
A Vavilina-Halstead - 2024 - escholarship.org
… , suggesting distinct but complementary roles for the two … differentiation is unable to establish
the mechanisms needed … -HSPCs led to upregulation of B lymphoid genes (IL7R, EBF1…
the mechanisms needed … -HSPCs led to upregulation of B lymphoid genes (IL7R, EBF1…
Single cell dissection of developmental origins and transcriptional heterogeneity in B-cell acute lymphoblastic leukemia
… Single cell characterization of B-lymphoid differentiation and leukemic cell states during
chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable …
chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable …
[HTML][HTML] Transcription factor TFII-I fine tunes innate properties of B lymphocytes
The ubiquitously expressed transcription factor TFII-I is a multifunctional protein with pleiotropic
roles in gene regulation. TFII-I associated polymorphisms are implicated in Sjögren’s …
roles in gene regulation. TFII-I associated polymorphisms are implicated in Sjögren’s …