… , and various skin blistering diseases severely impacts quality of … both FcRn and the family
of canonical FcγRs are central to IgG (… on how IVIg may modulate IgG-dependent autoimmune …

… trials are completed, the information that IVIg preparations contain … of IgG derived from IVIg
administrations saturate the FcRn so … IVIg causes a dose-dependent downregulation on their …

… FcRn binds to the Fc portion of IgGs in a pH-dependent … state of knowledge of FcRn–IgG
immunobiology, with an … infectious diseases and cancer, and in the promotion of autoimmunity, …

… In the unlikely event that the author did not send a complete … to IVIg and SCIg for the
treatment of autoimmune diseases where its mechanism has been suggested to be Fc-dependent. …

… in multiple autoimmune diseases, reducing total IgG could … randomised 1:1 to efgartigimod
IV 10 mg/kg or placebo. A … In our study, an IgG response to T-cell dependent vaccines was …

… dependence on BTK for survival as compared to normal B cells; evidenced by the loss of
autoantibodies with maintenance of total … between FcRn and the Fc portion of IgG molecules, at …

… a debilitating autoimmune blistering disorder mediated by IgG … Resulting blisters of the skin
and mucous membranes are … seven vulgaris) completed five weekly intravenous doses of …

… As such, in addition to liver synthesis, pH-dependent FcRn … Treatment with intravenous
immunoglobulin (IVIg) may further … in FcRn inhibitor design, such as format (full-length IgG vs Fc …

… IV-inhibitors, checkpoint inhibitors), neurological diseases as … low while total IgG and
virus-specific IgG concentrations were … Inhibitors of FcRn are in testing for both pemphigus and BP. …

… Normally, IgG antibodies bind to FcRn to return via … of Fas-FasL interaction by IVIg, not
dependent on their dose. Jagadeesan … or mucous membranes are typical of pemphigoid diseases, …