… on bacterial P450 X-ray crystal structures to rabbit and human P450 … and postdoctoral fellow
in two different areas of research, I … /K262R) with amlodipine (violet sticks) bound that helped …

… Our results showed that the induced-fit binding of these … structure of rabbit CYP2B4, and the
preferred binding pose that … the human CYP2B6 in complex with two amlodipine molecules (…

… ) Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome
P450 2B4 revealed upon binding multiple amlodipine molecules. Biochemistry 51(37):7225-38. …

… The human CYP2B6 was detected to accommodate two amlodipine (AD) molecules as
markers, the … were made upon kinetic analysis of NP oxyfunctionalization by the rabbit isozyme. …

… structure, that of rabbit microsomal CYP2C5, was not … , we have many co‐crystal structures
available for each P450 … calcium channel blockers amlodipine and nifedipine. We found that …

… various conformations over time and to function in both binding to … In both sets of simulations,
molecular visualization revealed … multiple conformations and hydrophobic interactions with …

… CYP121 undergoes a global conformational change in response to … also showed significant
disruption in substrate binding. … that mutations in two unique cYY-binding residues within the …

… In part 1, we showed that numerical method analysis of the … of P450 kinetics, including
multiple-substrate binding and … to identify which substrate molecule is metabolized to which …

… Cytochromes P450 are versatile enzymes that function in … to promote a substrate-bound
conformation that was preexisting in … In the ligand-free sample, we detected two primary narrow …

… multilevel model for estimating two covariance matrices that … the illustrative examples of
cytochrome P450 family 2 enzymes … the other two-level method used in this study, showed results …