[HTML][HTML] Type IV coupling proteins as potential targets to control the dissemination of antibiotic resistance

I Álvarez-Rodríguez, L Arana… - Frontiers in Molecular …, 2020 - frontiersin.org
… a type IV secretion system (T4SS) as conjugative machinery. But while conjugative plasmids
code for all the proteins needed … Conjugative plasmid protein TrwB, an integral membrane

[HTML][HTML] Conjugative Coupling Proteins and the Role of Their Domains in Conjugation, Secondary Structure and in vivo Subcellular Location

I Álvarez-Rodríguez, B Ugarte-Uribe… - Frontiers in Molecular …, 2020 - frontiersin.org
… elements in the conjugative type IV secretion systems (T4SSs… ; (ii) TraG-J pairs, which are
also integral membrane proteins … roles in conjugative plasmid related and mobilizable plasmid

Primary architecture and energy requirements of Type III and Type IV secretion systems

ME Cabezón Navarro, F Valenzuela Gómez… - 2023 - repositorio.unican.es
membrane by VirB3 (TrwM), an integral membrane protein. … Of these, the coupling protein
VirD4 (TrwB) serves as the … of the relaxase protein (TrwC in R388) to the conjugative plasmid. …

[HTML][HTML] Primary architecture and energy requirements of Type III and Type IV secretion systems

E Cabezón, F Valenzuela-Gómez… - Frontiers in Cellular and …, 2023 - frontiersin.org
membrane by VirB3 (TrwM), an integral membrane protein. … Of these, the coupling protein
VirD4 (TrwB) serves as the … of the relaxase protein (TrwC in R388) to the conjugative plasmid. …

Characterization of an atypical but widespread type IV secretion system for transfer of the integrative and conjugative element (ICEclc) in Pseudomonas putida

A Daveri, V Benigno, JR van der Meer - Nucleic Acids Research, 2023 - academic.oup.com
… in ICE-type IV secretion system assembly were revealed by … evolutionary distinct type IV
conjugative system with transfer … ) that is conjugated through a type IV secretion system (T4SS) …

Type IV secretion systems: advances in structure, function, and activation

TRD Costa, L Harb, P Khara, L Zeng, B Hu… - Molecular …, 2021 - Wiley Online Library
… : (i) conjugation systems that mediate interbacterial DNA … and the VirD4 receptor or type IV
coupling protein (T4CP). … , nucleates assembly of the integral membrane portion of the IMC. …

[HTML][HTML] Protein dynamics in F-like bacterial conjugation

N Bragagnolo, C Rodriguez, N Samari-Kermani… - Biomedicines, 2020 - mdpi.com
Conjugative plasmids are transmissible through the type IV … , type 4 pili, which are generated
by type 2 secretion systems, … The essential coupling protein TraD is a 717 aa IM protein

[HTML][HTML] Chimeric systems composed of swapped Tra subunits between distantly-related F plasmids reveal striking plasticity among type IV secretion machines

K Kishida, YG Li, N Ogawa-Kishida, P Khara… - PLoS …, 2024 - journals.plos.org
… , comprise the superfamily of type IV secretion systems (T4SSs). … or type IV coupling
protein (T4CP), an inner membrane … intact T4SS encoded by conjugative plasmid R388 (T4SS …

Chimeric systems composed of swapped Tra subunits between distantly-related F plasmids reveal striking plasticity among type IV secretion machines

P Christie, K Kishida, YG Li, N Ogawa-Kishida, P Khara… - bioRxiv, 2023 - biorxiv.org
… effectors by pathogenic species, comprise the superfamily of type IV secretion … The
bacterial type IV secretion systems (T4SSs) comprise a functionally and structurally diverse …

[HTML][HTML] Biology and engineering of integrative and conjugative elements: Construction and analyses of hybrid ICEs reveal element functions that affect species …

EL Bean, C Herman, ME Anderson… - PLoS …, 2022 - journals.plos.org
… ICEs encode proteins that comprise the conjugation machinery, a type IV secretion system
(… element containing a coupling protein swap was able to function for conjugative transfer (…