Clinical value of measurable residual disease in acute lymphoblastic leukemia

K Hein, N Short, E Jabbour, M Yilmaz - Blood and Lymphatic …, 2022 - Taylor & Francis
… These relapses are caused by the persistent leukemic blasts … Citation40 Achievement of
complete molecular remission (… Standardisation and consensus guidelines for minimal residual

Evaluation and management of measurable residual disease in acute lymphoblastic leukemia

I Abou Dalle, E Jabbour… - … advances in hematology, 2020 - journals.sagepub.com
complete remission. However, up to half of patients have persistent minimal/measurable
residual … kinase inhibitor (TKI) and achieved a complete molecular response (CMR; defined as …

The minimal residual disease using liquid biopsies in hematological malignancies

R Colmenares, N Álvarez, S Barrio, J Martínez-López… - Cancers, 2022 - mdpi.com
… or biopsies, cytogenetic analyses, and molecular testing using … dynamics, and the persistent
molecular MRD status in the … was associated with a conventional remission status, and the …

Utilizing the prognostic impact of minimal residual disease in treatment decisions for pediatric acute lymphoblastic leukemia

F Ceppi, F Rizzati, A Colombini, V Conter… - … of Hematology, 2021 - Taylor & Francis
… : BM in complete remission can contain leukemic … molecular genetics and MRD data were
integrated into a single combined classification to refine treatment stratification in the ongoing

Early achievement of measurable residual disease (MRD)-negative complete remission as predictor of outcome after myeloablative allogeneic hematopoietic cell …

AP Hoffmann, AL Besch, M Othus, LM Morsink… - Bone marrow …, 2020 - nature.com
… In the meantime, to ensure continued support, we are … neg CR or CR with incomplete
hematologic recovery (CRi) and were … Moreover, information on molecular and FISH testing was …

Minimal or Measurable Residual Disease in Acute Lymphoblastic Leukemia

S Paul, C Rausch, HM Kantarjian, E Jabbour - Acute Leukemias, 2021 - Springer
Molecular relapse has also been noted to precede hematologic relapse by about 2.6 months…
proceeded to alloHSCT in continuous complete remission after blinatumomab were alive, …

Next-generation sequencing of minimal residual disease for predicting relapse after tisagenlecleucel in children and young adults with acute lymphoblastic leukemia

MA Pulsipher, X Han, SL Maude, TW Laetsch… - Blood cancer …, 2022 - AACR
complete remission (CR)/CR with incomplete hematologic … A final intriguing outcome is our
observation that continued B-… Further study of this population, including detailed molecular

… receptor T cell therapy improve the prognosis of pediatric acute lymphoblastic leukemia with persistent/recurrent minimal residual disease in first complete remission

G Hu, Y Cheng, Y Zuo, Y Chang, P Suo, J Wu… - Frontiers in …, 2022 - frontiersin.org
Background The presence of minimal residual disease (MRD) is an independent risk factor
for poor prognosis in patients with acute lymphoblastic leukemia (ALL). Moreover, the role of …

Effect of sustained measurable residue disease negativity and post‐remission treatment selection on the prognosis of acute lymphoblastic leukemia in adults

J Yu, Y Luo, L Wang, T Wang, M Ye, J Chen… - Cancer …, 2024 - Wiley Online Library
complete remission (CR1) but with persistent measurable … Patients who did not reach
hematologic CR after 2 cycles of … patients achieved sustained minimal residual disease negativity. …

[HTML][HTML] Measurable residual disease monitoring provides insufficient lead-time to prevent morphological relapse in the majority of patients with core-binding factor …

R Puckrin, EG Atenafu, JO Claudio, S Chan… - …, 2021 - ncbi.nlm.nih.gov
… -established in hematologic malignancies with … Persistent molecular disease continued
for a median of 1.5 years and up to a maximum of 3.4 years from the time of complete remission