… cardiac and skeletal muscle function in dystrophin-deficient … The loss of dystrophin and DAPC
integrity in DMD makes … by the dysfunctional contractile apparatus of skeletal muscles [115]…

… to mechanical muscle contraction. Fully differentiated … from injuries or loss of the capacity
to repair muscle after injury is … muscular dystrophies that show loss of sarcolemma integrity, …

… contractile regimes induced the loss of myotube integrity, … of dystrophin levels due to limited
uptake by skeletal muscle … of long twitch contraction cycles on sarcolemmal integrity in the …

… at the muscle periphery, as well as providing sarcolemmal stabilization and contractile force
… in (i) the provision of sarcolemmal membrane integrity via a stabilizing linkage between the …

… the dystrophin protein, compromising the structural integrity … decrease in muscle ex vivo
contractile function as compared … dysferlin function to compensate for the loss of dystrophin in the …

… to the myofibres or function in regulating sarcolemmal integrity, … In skeletal muscle, dystrophin
is enriched at costameres, … the contractile unit of the myofibre — connect to the sarcolemma …

… a critical role in maintaining the integrity of the sarcolemma. … Dystrophin further acts to
mitigate contraction-induced injury … Improvement in skeletal muscle function enabled higher …

… most basic units that drive skeletal muscle contraction, namely (a) … a loss in sarcolemmal
integrity making muscle vulnerable to stresses leading to various types of muscular dystrophies …

… that the sarcolemma and its costameric links to nearby contractile … values determined for
muscles lacking dystrophin or synemin … the peripheral myofibrils and the sarcolemma were lost. …

… from the sarcolemma and renders muscle prone to contraction-… We have shown that loss of
dystrophin causes aberrant … study and took responsibility for the integrity of the data and the …