Strategies to overcome/penetrate the BBB for systemic nanoparticle delivery to the brain/brain tumor

HJ Liu, P Xu - Advanced drug delivery reviews, 2022 - Elsevier
… tight junctions (TJs) through a number of transmembrane proteins (such as occludin, claudins,
… and the penetrating efficiency of BBTB for macromolecule and nanoparticles are highly …

Nanoparticles-mediated ion channels manipulation: From their membrane interactions to bioapplications

Q Huang, W Zhu, X Gao, X Liu, Z Zhang… - Advanced Drug Delivery …, 2023 - Elsevier
… Ion channels are transmembrane proteins ubiquitously … Recently, nanoparticles-mediated
ion channel manipulation … Thanks the advantages of their unique properties, nanoparticles can …

Elucidating collective translocation of nanoparticles across the skin lipid matrix: a molecular dynamics study

Y Badhe, P Sharma, R Gupta, B Rai - Nanoscale Advances, 2023 - pubs.rsc.org
co-operative transport of NPs across the cell membrane. Yue and Xianren Zhang reported
the cooperative effect of nanoparticle … bigger sized nanoparticles penetrated independently. …

Ligand-modified erythrocyte membrane-cloaked metal–organic framework nanoparticles for targeted antitumor therapy

Y Lin, Y Zhong, Y Chen, L Li, G Chen… - Molecular …, 2020 - ACS Publications
… of ZIF-8 at different concentrations (n = 3) (the bottles inserted in panel (A) were eppendorf
tubes, which can be clearly observed from the state of hemolysis of nanoparticles at different …

Permeation of nanoparticles across the intestinal lipid membrane: dependence on shape and surface chemistry studied through molecular simulations

R Gupta, Y Badhe, S Mitragotri, B Rai - Nanoscale, 2020 - pubs.rsc.org
… , the efficacy of nanoparticle penetration across the lipid layer … , apolar and nonpolar
nanoparticles were found to locate in … that the nanoparticles translocated in a cooperative manner …

Association mechanism of peptide-coated metal nanoparticles with model membranes: A coarse-grained study

S Franco-Ulloa, D Guarnieri, L Riccardi… - Journal of Chemical …, 2021 - ACS Publications
nanoparticles with lipid bilayers. (a) Free energy profiles for the bare (NP0) and citrate-capped
(CitNP) nanoparticles … both the outer aqueous phase and the transmembrane fatty phase. …

Simulation of nanoparticles interacting with a cell membrane: probing the structural basis and potential biomedical application

X Zhang, G Ma, W Wei - NPG Asia Materials, 2021 - nature.com
… NPs was a size-dependent cooperative process. That is, smaller NPs … transmembrane
regions of membrane proteins are important because they are closely related to transmembrane

Curvature-mediated pair interactions of soft nanoparticles adhered to a cell membrane

T Chen, Y Zhang, X Li, C Li, T Lu, S Xiao… - Journal of Chemical …, 2021 - ACS Publications
cooperation to independence, while enhancing the NP softness requires a stronger adhesion
to achieve the cooperative … mediated transmembrane transport of single dendrimer-like soft …

How nanoparticles open the paracellular route of biological barriers: mechanisms, applications, and prospects

J Wu, Z Zhu, W Liu, Y Zhang, Y Kang, J Liu, C Hu… - ACS …, 2022 - ACS Publications
… have established that NPs may penetrate biological barriers and … was the earliest integral
transmembrane component of the … The second approach involves cooperation with particular …

Polyhedral oligomeric silsesquioxane‐based nanoparticles for efficient chemotherapy of glioblastoma

X Zhong, G Wei, B Liu, C Wang, J Wang, Y Lu, W Cui… - Small, 2023 - Wiley Online Library
… To evaluate the ability of nanoparticles to penetrate the BBB, a conventional BBB model
was constructed in vitro (Figure 2d). A transmembrane resistance over 200 Ω cm −2 indicated …