… the presence of BRAF V600E mutation correlated with worse … with germline mutations present
with left-sided colon cancer at a … impact of BRAF V600E mutation and MLH1/PMS2 loss on …

… germline mutations versus sporadic mutations, which include but not limited to those with
BRAF V600E mutation with MLH1 promoter hypermethylation. … MMR-D tumors, BRAF mutations …

… by germline mutations in mismatch repair (MMR) genes (MLH1… for both MLH1 methylation
and BRAF mutation we had germline … Lynch Syndrome with a germline PV in MLH1 gene. One …

… V600E mutations (9 had somatic mutations of MMR genes) in … BRAF mutations are correlated
with MLH1 methylation,40, … MSI tumors could develop through MLH1 promoter methylation …

… MMR gene mutations may be present in germline DNA or can occur as somatic events within
a tumour… rare or novel mutations are found and these can require correlation with IHC and …

… germline mutation of DNA mismatch repair (MMR) genes. … by somatic MLH1 methylation
and not having tumor tissues … A similar relationship exists between MLH1 (primary protein) …

… brain tumors and can be induced by germline or sporadic … the four MLH1-mutant tumors,
complete loss of both MLH1 and … MMR protein was 100% correlated with MMR gene mutation in …

… of germline pathogenic variants in other non-MMR cancer … Given that MSI and IHC are
highly correlated, we generated … integrating BRAF mutation or MLH1 methylation status in our …

… BRAF V600E mutation by IHC and NGS, and twenty cases showed loss of MLH1 protein and
were positive for MLH1 hypermethylation… deleterious germline mutation in one of the MMR …

… germline pathogenic variants or MLH1 hypermethylation. … whose methylation status is
strongly correlated with MLH1 … of MLH1 promoter hypermethylation over BRAF testing and …