… in T cells following TCR activation with costimulation and is … T cells offer a particularly promising
approach to modulate T-… glutamine metabolism can become uncoupled, and inhibition of …

… expression can also hinder co-stimulation during T cells’ activation [… The uncoupling response,
which leaks protons across the … No such modulation of T-helper subsets was found in the …

… (TNF)-α acts to uncouple the cell to TCR signal transduction … Memory T-cell subsets through
the alteration of TCR signalling, costimulation, transcriptional regulation, and the modulation …

… However, a fraction of surviving T cells can form memory T cells… naïve T cells require a
second signal via costimulatory … metabolism modulating agents during TIL and CAR T cell …

… modulate the differentiation or function of specific T-cell … Engagement of the TCR, together
with costimulation during cell … Importantly, to uncouple the relevance of aerobic glycolysis …

… member receptor and costimulatory molecule CD27, the cell adhesion molecule L-selectin
(… In the first part, I tested whether modulation of specific TFs expression led to altered memory …

… in maximizing CD4 + T cell co-stimulation and the induction of … -phenylhydrazone (FCCP;
an uncoupling agent) to obtain the … By hampering the glycolytic pathway and modulating …

… continuous TCR signaling without co-stimulatory signals, which induces ‘T cell anergy’. …
These findings demonstrate that pharmacologic modulation of NR4a activity or expression …

… of functional memory cells were uncoupled. Consistent with … We also show that the concomitant
modulation of TCR and IL… a safeguard mechanism to prevent memory T cell clones to be …

… T cells (Tconvs) mediate adaptive immune responses, whereas regulatory T cells (Tregs)
suppress those responses … on the stage of the immune response and their environment, with an …