Histone deacetylases as targets in autoimmune and autoinflammatory diseases

P Hamminger, R Rica, W Ellmeier - Advances in Immunology, 2020 - Elsevier
… .) that have to be integrated into lineage-specific transcriptional … Histone acetylation and
deacetylation are regulated by … in the deacetylation of histones and a closed chromatin structure…

[HTML][HTML] Key players in HIV-1 transcriptional regulation: targets for a functional cure

L Mori, ST Valente - Viruses, 2020 - mdpi.com
… , integration site, and the surrounding chromatin environment. … groups are removed by
histone deacetylases (HDACs). … tighter chromatin environment and a loss of RNAPII occupancy

Cellular gene modulation of HIV-infected CD4 T cells in response to serial treatment with the histone deacetylase inhibitor vorinostat

JW Maxwell, SD Falcinelli, A Nefedov… - Journal of …, 2020 - Am Soc Microbiol
… IMPORTANCE Histone deacetylase inhibitors are widely … VOR, an HDACi, induces
histone acetylation and chromatin … in chromatin structure by preventing the deacetylation of …

[HTML][HTML] Epigenetic mechanisms of HIV-1 persistence

R Verdikt, O Hernalsteens, C Van Lint - Vaccines, 2021 - mdpi.com
… -1 DNA and before its integration in the host chromatin [43]. In … in coordinating nucleosome
occupancy, possibly through … with gene activation, histone deacetylation is associated with …

[HTML][HTML] HIV expression in infected T cell clones

JW Rausch, S Parvez, S Pathak, AA Capoferri… - Viruses, 2024 - mdpi.com
… the initial chromatin-free state of the pre-integrative HIV DNA … Histone deacetylases (HDACs)
erase the acetylation of … transcriptional activity, and capacity for latent proviral activation by …

Epigenetic compound screening uncovers small molecules for reactivation of latent HIV-1

A Zutz, L Chen, F Sippl, A Humpe… - Antimicrobial Agents …, 2020 - Am Soc Microbiol
… , especially deacetylation events by histone deacetylases (… the repressive SWI/SNF chromatin
remodeling machinery (46), … likely also resemble different areas of integration, as well as …

Nanoparticle delivery of Tat synergizes with classical latency reversal agents to express HIV antigen targets

SLM Raines, SD Falcinelli, JJ Peterson… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
… However, the persistence of a quiescent reservoir of integrated … Tat also recruits several host
proteins with chromatin … -TEFb and transactivate the promoter in any capacity, as even TAR-…

In vitro Pharmacokinetic/Pharmacodynamic modeling of HIV latency reversal by novel HDAC inhibitors using an automated platform

W Newhard, M Patel, J Cassaday… - … the Science of Drug …, 2021 - journals.sagepub.com
… The kinetics of histone deacetylation after compound … chromatin restriction of transcription.
The delay in the peak of … cell line that contains a single integrated HIV provirus. Future studies …

[HTML][HTML] Balance between retroviral latency and transcription: based on HIV model

A Pluta, JP Jaworski, CN Cortés-Rubio - Pathogens, 2020 - mdpi.com
… The efficiency of the initial transcription of integrated DNA from 5′ … Histone deacetylation
may be important for blocking HIV-1 … Highlighted is the extraordinary capacity of lentiviruses to …

[HTML][HTML] Block-and-lock strategies to cure HIV infection

G Vansant, A Bruggemans, J Janssens, Z Debyser - Viruses, 2020 - mdpi.com
integration status of the viral DNA: pre- and post-integration … by increasing deacetylated
histone 3 occupancy at Nuc-1 [91]… while the activating chromatin remodeling complex PBAF was …