Glycopeptide antibiotics: Genetics, chemistry, and new screening approaches

O Yushchuk, B Ostash - … from Actinomycetes: Diversity, Ecology and Drug …, 2022 - Springer
Streptomyces, but … sulfotransferases offered more interesting case, being able to sulfate
teicoplanin aglycone at aa-3 (Teg12), aa-4 (Teg14), and aa-6 (Teg13). Crystal structures of StaL, …

Functional characterization of the sulfotransferase TotS in totopotensamide biosynthesis

B Tan, Q Zhang, L Zhang, Y Zhu, C Zhang - Tetrahedron, 2022 - Elsevier
… BGC (about 92 kb) in Streptomyces lividans TK64, and the characterization of … crystal
structures of well-known glycopeptide antibiotic sulfotransferase StaL and other sulfotransferases […

[HTML][HTML] Genome mining of sulfonated lanthipeptides reveals unique cyclic peptide sulfotransferases

M Wang, WW Li, Z Cao, J Sun, J Xiong, SQ Tao… - … Pharmaceutica Sinica B, 2024 - Elsevier
… of RiPP class-defining enzymes and sulfotransferase (ST), and … Upon expressing these
BGCs, we characterized the structures of … in Streptomyces cinnamoneus DSM 41675 (ssl) and …

[HTML][HTML] Crystal structure of tick tyrosylprotein sulfotransferase reveals the activation mechanism of the tick anticoagulant protein madanin

M Yoshimura, T Teramoto, H Asano, Y Iwamoto… - Journal of Biological …, 2024 - ASBMB
… in a sulfuryl transfer reaction: crystal structure of a mouse sulfotransferase, mSULT1D1,
complexed … Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of …

Structural diversity, biosynthesis, and biological functions of lipopeptides from Streptomyces

S Zhang, Y Chen, J Zhu, Q Lu, MJ Cryle… - Natural Product …, 2023 - pubs.rsc.org
… the X-domain from glycopeptide antibiotic biosynthesis and I-… totopotensamide C is performed
by the sulfotransferase TotS. … toyocaensisStaL led to production of two novel derivatives …

[HTML][HTML] Resurrecting ancestral antibiotics: unveiling the origins of modern lipid II targeting glycopeptides

MH Hansen, M Adamek, D Iftime, D Petras… - Nature …, 2023 - nature.com
… of HGT into Amycolatopsis and Streptomyces. This process was … In this structure, the substrate
binding pocket … for comparison to other structures; D190 in crystal structure), A197 (A191) …

Combinatorial biosynthesis of sulfated benzenediol lactones with a phenolic sulfotransferase from Fusarium graminearum PH-1

L Xie, D Xiao, X Wang, C Wang, J Bai, Q Yue, H Yue… - Msphere, 2020 - Am Soc Microbiol
… SULT from Streptomyces toyocaensis (PDB: 4EEC; Fig. S7B in reference 36). Consistent …
sulfotransferase SULT1B1 (992 Å 3 ), the S. toyocaensis glycopeptide antibiotic SULT StaL (…

[HTML][HTML] Coelenterazine sulfotransferase from Renilla muelleri

G Tzertzinis, B Baker, J Benner, E Brown, IR Corrêa Jr… - Plos one, 2022 - journals.plos.org
… bioluminescence related sulfotransferase system report from 2019, a sulfotransferase for …
The firefly luciferin sulfotransferase was shown to catalyze the formation of the storage form, …

[HTML][HTML] Structural insights into the putative bacterial acetylcholinesterase ChoE and its substrate inhibition mechanism

TA To, C Gagné-Thivierge, M Couture, P Lagüe… - Journal of Biological …, 2020 - ASBMB
… the structures and molecular mechanism of prokaryotic acetylcholinesterases. We report here
the structural … The crystal structure of ChoE at 1.35 Å resolution revealed that this enzyme …