Gingival fibroblast activation by Porphyromonas gingivalis is driven by TLR2 and is independent of the LPS‐TLR4 axis

A Schuster, E Nieboga, M Kantorowicz… - European Journal of …, 2024 - Wiley Online Library
… are weak activators of GF innate immune responses compared with live P. gingivalis or other
relevant virulence factors, such as P. gingivalis fimbriae or LPS from Escherichia coli. GF’s …

Exposure to Porphyromonas gingivalis Induces Production of Proinflammatory Cytokine via TLR2 from Human Respiratory Epithelial Cells

N Watanabe, S Yokoe, Y Ogata, S Sato… - Journal of Clinical …, 2020 - mdpi.com
gingivalis, 293-TLR2 cells alone were activated in a density-dependent manner (Figure 4A).
These findings suggest that the observed cytokine production by BEAS-2B and Detroit 562 …

Porphyromonas gingivalis induction of TLR2 association with Vinculin enables PI3K activation and immune evasion

K Pandi, S Angabo, J Gnanasekaran, H Makkawi… - PLoS …, 2023 - journals.plos.org
gingivalis benefits from TLR2-driven signaling via activation of PI3K. … TLR2 protein-protein
interactions induced in response to P. gingivalis, and identified an interaction between TLR2

P. gingivalis–Induced TLR2 Interactome Analysis Reveals Association with PARP9

K Pandi, S Angabo, H Makkawi… - Journal of Dental …, 2024 - journals.sagepub.com
… Among the top protein clusters induced to interact with TLR2 following macrophage
activation, we observed mono-ADP-ribosyltransferase protein 9 (PARP9) and its known complex …

Porphyromonas gingivalis: Immune Subversion Activities and Role in Periodontal Dysbiosis

G Hajishengallis, PI Diaz - Current oral health reports, 2020 - Springer
TLR2 responds to … activation of TLR2/1 or TLR2/6 complexes [76]. Moreover, TLRs engage
in signaling crosstalk with the complement system, apparently to coordinate innate immunity

A novel phosphoglycerol serine-glycine lipodipeptide of Porphyromonas gingivalis is a TLR2 ligand

FC Nichols, RB Clark, MW Maciejewski… - Journal of lipid …, 2020 - ASBMB
Cutting edge: TLR2 is required for the innate response to Porphyromonas gingivalis:
activation leads to bacterial persistence and TLR2 deficiency attenuates induced alveolar bone …

Pam2CSK4 (TLR2 agonist) induces periodontal destruction in mice

JAC Souza, FAC Magalhães, GJPL Oliveira… - Brazilian Oral …, 2020 - SciELO Brasil
Cutting Edge: TLR2 is required for the innate response to Porphyromonas gingivalis:
activation leads to bacterial persistence and TLR2 deficiency attenuates induced alveolar bone …

[HTML][HTML] TLR2 and TLR4 differentially regulate the osteogenic capacity of human periodontal ligament fibroblasts

S Seubbuk, R Surarit, D Stephens… - Journal of the …, 2021 - ncbi.nlm.nih.gov
… While the role of TLR signaling in the innate immune response … the hypothesis that TLR2
and TLR4 activation will mediate … of TLR2 and TLR4 in Porphyromonas gingivalis vs. ligature-…

Different expression patterns of inflammatory cytokines induced by lipopolysaccharides from Escherichia coli or Porphyromonas gingivalis in human dental pulp …

C Lan, S Chen, S Jiang, H Lei, Z Cai, X Huang - BMC Oral Health, 2022 - Springer
… of TLR4 and TLR2 in hDPSCs response to E. coli and … activation of the host immune response.
So that to escape the monitoring of immune cells, it is easier to enter the pulp tissue for P. …

TLR3-Dependent activation of TLR2 endogenous ligands via the MyD88 signaling pathway augments the innate immune response

HS Teixeira, J Zhao, E Kazmierski, DF Kinane… - Cells, 2020 - mdpi.com
… pathogen Porphyromonas gingivalis [15]. As such, … the response of B cells, a significant
reduction in B cell activation was observed. This study also noted that the activation of TLR2