[HTML][HTML] Treponema denticola dentilisin triggered TLR2/MyD88 activation upregulates a tissue destructive program involving MMPs via Sp1 in human oral cells

S Ganther, A Radaic, E Malone, P Kamarajan… - PLoS …, 2021 - journals.plos.org
… host response, which propagates the destructive responses … on species such as
Porphyromonas gingivalis, Fusbacterium … to activate TLR2/4 to stimulate an innate immune

[PDF][PDF] The role of soluble TLR-2 in the immunopathogenesis of Gingivitis

BH Al-Ghurabi - International Medical Journal, 2021 - researchgate.net
immune system and plays an essential role in pathogen recognition and innate immunity
activation. … attractant protein□ 1 after stimulation with Porphyromonas gingivalis via toll□ like …

[HTML][HTML] Porphyromonas gingivalis Mfa1 Induces Chemokine and Cell Adhesion Molecules in Mouse Gingival Fibroblasts via Toll-Like Receptors

Y Takayanagi, T Kikuchi, Y Hasegawa, Y Naiki… - Journal of Clinical …, 2020 - mdpi.com
… and the host innate immune response to pathogens is … gingivalis to evade the innate host
defense in gingival tissues [39]. FimA activates human peripheral blood monocytes via TLR2

[HTML][HTML] hTERT-immortalized gingival fibroblasts respond to cytokines but fail to mimic primary cell responses to Porphyromonas gingivalis

KB Lagosz-Cwik, A Wielento, W Lipska… - Scientific reports, 2021 - nature.com
… The innate immune response to P. … of diminished TLR2 expression, we analyzed the effects
of TLR2-specific ligands, Pam2CSK4 and Pam3CSK4, on TIGF inflammatory activation. Both …

Glycine lipids of Porphyromonas gingivalis are agonists for Toll-like receptor 2

FC Nichols, RB Clark, Y Liu, AA Provatas… - … and immunity, 2020 - Am Soc Microbiol
… these lipid classes to activate mammalian cells and whether TLR2 is engaged in biological
responses. Mass spectrometry was … Cutting edge: TLR2 is required for the innate response to …

Pulp innate immune defense: translational opportunities

HF Duncan, PR Cooper - Journal of Endodontics, 2020 - Elsevier
… Furthermore, certain bacteria, such as Enterococcus faecalis, Porphyromonas gingivalis
TLR-2, -4, and -9 as well as via the inflammasome. Subsequently, this binding triggers activation

[HTML][HTML] Toll-like receptors and dental mesenchymal stromal cells

O Andrukhov - Frontiers in Oral Health, 2021 - frontiersin.org
activate TLR-2 [4, 64–66]; bacterial flagellin activates TLR-5 [67]. A microarray study showed
that Porphyromonas gingivalis secreted products activated … and immune response [68], and …

[HTML][HTML] Porphyromonas gingivalis Fimbriae Induce Osteoclastogenesis via Toll-like Receptors in RAW264 Cells

Y Suzuki, T Kikuchi, H Goto, Y Takayanagi… - International Journal of …, 2022 - mdpi.com
innate immune response to pathogens is mediated primarily by TLR signaling [13]. TLR2
Therefore, the effects of Mfa1 on osteoclast differentiation and activation in the present study …

[HTML][HTML] Toll-like receptor signaling and immune regulatory lymphocytes in periodontal disease

Y Gu, X Han - International journal of molecular sciences, 2020 - mdpi.com
… of periodontitis, such as Porphyromonas gingivalis (P. … event of the innate and adaptive
immune responses leading to … the B10 activation and expansion by TLR2/4/9 agonists (P. …

[HTML][HTML] The Anti-Inflammatory Effect of SDF-1 Derived Peptide on Porphyromonas gingivalis Infection via Regulation of NLRP3 and AIM2 Inflammasome

SY Kim, MK Son, JH Park, HS Na, J Chung - Pathogens, 2024 - mdpi.com
… inflammasome that regulates innate immune responses and as … to AIM2 inflammasome
activation and IL-1β secretion [16]. … activation of NLRP3, the AIM2 inflammasome, and the TLR2/4 …