… Rb3 Inhibits Pro-Inflammatory Cytokines via MAPK/AKT/NF-κB Pathways and Attenuates Rat Alveolar Bone Resorption in Response to Porphyromonas gingivalis …

M Sun, Y Ji, Z Li, R Chen, S Zhou, C Liu, M Du - Molecules, 2020 - mdpi.com
Activation of the immune response in periodontal tissues may initially be intended to protect;
… We also found that the enhancement of TLR2 mRNA induced by 4 days of P. gingivalis LPS …

Fusobacterium nucleatum Extracellular Vesicles Modulate Gut Epithelial Cell Innate Immunity via FomA and TLR2

…, A Malabirade, J Habier, P Wilmes - Frontiers in …, 2020 - frontiersin.org
… role of TLR2 and FomA as major modulators of the gut epithelium immune responses to F. …
Our work indicates that if TLR2 activation by EVs do not disrupt healthy intestinal epithelium, …

Host insulin resistance caused by Porphyromonas gingivalis-review of recent progresses

S Jia, X Li, Q Du - Frontiers in Cellular and Infection Microbiology, 2023 - frontiersin.org
gingivalis induces insulin resistance involves the activation of … The innate immune
receptors TLR2 and TLR4 are pattern … gingivalis interferes with the innate immune response in …

Virulence of the pathogen Porphyromonas gingivalis is controlled by the CRISPR-Cas protein Cas3

J Solbiati, A Duran-Pinedo, F Godoy Rocha… - Msystems, 2020 - Am Soc Microbiol
… Toll-like receptor 2 (TLR2), may suggest activation of TLR2 in a MyD88-dependent manner.
gingivalis, as well as on the immune response of THP-1 cells. We observed an upregulation …

Immunomodulatory Strategies as Adjunctive Therapies to the Treatment of Periodontal Disease

A Altitinchi - 2021 - search.proquest.com
… an imbalanced immune responseactivation of TLR2 signaling in gingival epithelial cells
is more pronounced than TLR 4, inducing a strong pro-inflammatory response via the activation

[HTML][HTML] JAK3 restrains inflammatory responses and protects against periodontal disease through Wnt3a signaling

L Lü, L Yakoumatos, J Ren, X Duan… - … : official publication of …, 2020 - ncbi.nlm.nih.gov
Porphyromonas gingivalisgingivalis activates Smurf1 through a de novo synthesized
cytokine, TGF-β1, which is produced in a C5aR/TLR2-dependent manner, and we found that P

Immunomodulation in the treatment of periodontitis: Progress and perspectives

B Yang, X Pang, Z Li, Z Chen, Y Wang - Frontiers in immunology, 2021 - frontiersin.org
… pathogenesis (9), and Porphyromonas gingivalis (P. … such as toll-like receptors 2 (TLR2),
TLR4, and nucleotide-… roles through activation of the acquired immune response (124, 125). …

Two Sjogren syndrome-associated oral bacteria, Prevotella melaninogenica and Rothia mucilaginosa, induce the upregulation of major histocompatibility complex …

J Lee, S Jeon, Y Choi - International Journal of Oral Biology, 2021 - koreascience.kr
… MHC I likely through TLR2 and TLR9 activation, while Rm-… the periodontal pathogen
Porphyromonas gingivalis, because … Cutting edge: recognition of Gram-positive bacterial cell wall …

Osteocytes directly regulate osteolysis via MYD88 signaling in bacterial bone infection

T Yoshimoto, M Kittaka, AAP Doan, R Urata… - Nature …, 2022 - nature.com
Porphyromonas gingivalis (Pg… TLR2-MYD88 axis in osteocytes and mature osteoblasts
directly controls Pg-induced alveolar bone loss because TLR2 signaling is known to be activated

Akkermansia muciniphila ameliorates the host response to Porphyromonas gingivalis-induced experimental periodontitis

H Mulhall - 2021 - search.proquest.com
… The polarization towards a M2 phenotype and manipulation of the immune response by A. …
from P. gingivalis can activate macrophages through atypical TLR2 signaling, promoting the …