… of Src and EGFR by Erb-B2 Receptor Tyrosine Kinase (ERBB4), which was reported to be
upregulated in 43% of patients with CRC, results in the upregulation of cyclooxygenase 2 (…

… , it has been demonstrated that fenugreek compounds inhibit the activity of the enzyme
cyclooxygenase2 (… untreated metastatic colorectal cancer." Journal of Clinical Oncology, 2004. …

… Due to its constitutive expression in most of the tissues, COX-1 is considered as housekeeping
enzyme. However its role in acute inflammation has been confirmed as arachidonic acid-…

… to be significantly increased in colorectal polyps and colorectal cancer, and COX-2 … colorectal
cancer has been carefully suggested [7]. It is well-established that the risk of colon cancer …

… Cyclooxygenase-2 (COX-2) enzyme is over expressed in oral … [110] had developed
mucoadhesive microspheres for site-specific delivery of valdecoxib to colorectal tumors in an attempt …

… To further outline the important role of PGE2 in colon carcinogenesis, different studies showed
that mPGES-1 deletion suppresses the development of intestinal tumors in ApcMin/+ and …

Background Although nonsteroidal anti‐inflammatory drugs (NSAIDs) reduce colorectal
cancer (CRC) risk, their role in preventing post‐colonoscopy CRC (PCCRC) remains …

… agents against the development of colorectal cancer and colorectal adenomas. Aspirin …
colorectal cancer chemoprevention. Although studies have shown up to 40% colorectal cancer …

… development of colon cancer later in life [18]. With this, we will discuss the role of obesity in
colorectal carcinoma, … In recent years, we have developed a refined understanding regarding …

… celecoxib, the only inhibitor of cyclooxygenase-2 (COX-2) with … /ER Ca 2 + -ATPase activity
in cancer cells. This study aimed to … colon cancer HCT116 cells with celecoxib reduced their …