… to various activating or inhibitory stimuli. Arachidonic acid is … primary haemostasis and
atherothrombosis is demonstrated … low-dose aspirin, a selective inhibitor of platelet COX-1. The …

… is associated with cyclooxygenase-2 expression in discrete … implicated in the reduced
atherothrombosis observed in mouse … with unintentional cyclooxygenase-2 inhibition (61) and the …

… In endothelial activation assays, there were no biologically significant changes in the
expression level of 7 potential endothelial injury markers for any of our COX inhibitor compounds …

… Aspirin modifies cyclooxygenase-2 (COX2) by acetylation in Ser 530 . This modification, …
the expression of adhesion molecules on human leukocytes in whole blood and to inhibit …

… This prostanoid plays a central role in atherothrombosis, as shown by the benefit of the
antiplatelet agent low-dose aspirin, a preferential inhibitor of platelet COX-1. Recent findings …

… Overall, we have established the eicosanoid profiles linked to inhibition of COX-1 in
platelets and in the remainder of the cardiovascular system and linked them to anti-and pro-…

… an important role in the pathogenesis of atherothrombosis and its thrombotic complications
effecting peripheral, coronary and cerebral arteries. Complete inhibition of COX-2 mediated …

… The inhibition of TXAS expression to synthesise TXA 2 and TP activation through TXAS
or … TP expression and TXA 2 release are elevated during vascular and atherothrombotic …

… As expected, NOS inhibition by L-NAME largely decreased … We found that either nonselective
or selective inhibition of … artery endothelial dysfunction in atherothrombotic stroke. Of note, …

… human volunteers inhibits platelet function while preserving hemostatic function. Vascular-wall-produced
PGE 2 exacerbates arterial thrombosis and atherothrombosis through platelet …