… Chronic myeloid leukemia is a clonal myeloproliferative disease whose origin involves
an alteration in the genome in the hematopoietic stem cell compartment. This change …

… detected by classical cytogenetics, but only by FISH or molecular genetic methods. Huntly et
… , which can only be detected by FISH or molecular genetic techniques such as RT-PCR, are …

Tyrosine-kinase inhibitors have changed the natural history of chronic myeloid leukaemia in
such a way that patients with adequate access to these agents, who are properly managed, …

… Cytogenetic studies and recent genetic studies using next-generation sequencing (NGS) …
domain mutations, but also additional cytogenetic and genetic abnormalities in CML. Additional …

… Chronic myeloid leukemia is a disease of hematopoietic stem cells. CML is a type of cancer
caused by the balanced translocations between the long arms of chromosomes 9 and 22, t(9;…

Atypical chronic myeloid leukemia, BCR-ABL1 negative (aCML) is a rare myelodysplastic … )
with a high rate of transformation to acute myeloid leukemia, and poor survival. Until now, the …

Chronic Myeloid Leukemia (CML) is a rare malignant proliferative disease of the hematopoietic
system, whose molecular … The Ph chromosome originates an aberrant fusion gene with …

… Chronic myelogenous leukemia (CML) is a chronic clonal myeloproliferative disease …
This chapter will review CML from its discovery, molecular and epigenetic mechanisms of …

… Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm that arises from
a … 9 and 22, and constitutes the cytogenetic hallmark of CML. It can be detected in …

… Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm and was the first …
The advances in cytogenetic and molecular assays are of great importance to the diagnosis, …