… and/or the cytoplasmic relocation and functional blockade of myeloid transcription factors …
profiles, even when only cases with a normal karyotype were considered (data not shown), …

… a cytoplasmic dislocation of the NPM1 protein. These mutations are unique to acute myeloid
leukemia … On the other hand, NPM1c are most common in normal karyotype AML, indicating …

… About 50–60% of acute myeloid leukemia patients with normal karyotype carry NPM1
mutations, which are characterized by cytoplasmic dislocation of the NPM1 protein. Nevertheless, …

… adult acute myeloid leukemia (AML) patients, and in 50–60% of cases with normal karyotype…
mutants and their aberrant accumulation in the cytoplasm of leukemic cells (NPM1c), the …

… acute myeloid leukemia (AML), being detected in 35% of all cases and in up to 60% of patients
with normal karyotype AML… Histograms and scatterplots of cytoplasmic nucleophosmin 1 (…

… Acute myeloid leukemia (AML) with nucleophosmin (NPM1) gene mutations is the most …
NPM1-mutated AML is characterized by cytoplasmic positivity for NPM1 at immunohistochemical …

… role in the pathogenesis of acute myeloid leukemia (AML) and is … From a morphologic point
of view, cytoplasmic NPM1 was … with cytoplasmic NPM1 exhibited a normal karyotype and a …

… The most frequently mutated genes in AML is Nucleophosmin-… Nucleophosmin-1 (NPM1)
defined as a nucleus cytoplasm … melting analysis in normal karyotype acute myeloid leukemia. …

… nucleophosmin (NPM1) gene encodes for a multifunctional protein with prominent nucleolar
localization that shuttles between nucleus and cytoplasm… associated with normal karyotype, …

… Nucleophosmin (NPM1) is a widely expressed protein predominantly located in the nucleolus
that continuously shuttles between nucleus and cytoplasm. … karyotype t(8;21) or inv(16). …