The anticancer action of a novel 1, 2, 4-triazine sulfonamide derivative in colon cancer cells

A Gornowicz, A Szymanowska, M Mojzych… - Molecules, 2021 - mdpi.com
… Recently, we examined the multi-targeted potential of a monoclonal antibody against
mucin 1 (MUC1) and a novel octahydropyrazino[2,1-a:5,4-a′]diisoquinoline derivative (OM-86II) …

Genotoxic Effects of New Azoloazine Derivatives with Antitumor Activity in MCF-7 Tumor Cell Culture

AH Al-Humain, DL Speranskiy, OY Rybalkina… - Pharmaceutical …, 2023 - Springer
… The genotoxic properties of three new azoloazine derivatives (azoloazines 1 – 3) exhibiting
cytotoxic activity were studied in an in vitro experiment using MCF-7 human breast cancer …

The Effect of Novel 7-methyl-5-phenyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine Sulfonamide Derivatives on Apoptosis and Autophagy in DLD-1 and HT-29 Colon …

A Gornowicz, A Szymanowska, M Mojzych… - International Journal of …, 2020 - mdpi.com
… that anticancer activity of 7-methyl-5-phenyl-pyrazolo[4,3-e]tetrazolo[4,5-b][1,2,4]triazine
derivatives … membrane decrease and extrinsic with increase of activity of caspase-8. Moreover, a …

Mucin 1 as a molecular target of a novel diisoquinoline derivative combined with anti-MUC1 antibody in AGS gastric cancer cells

A Gornowicz, W Szymanowski, K Bielawski, Z Kałuża… - Molecules, 2021 - mdpi.com
… mechanism of the anticancer action of a monoclonal … 45.8% and 34.3% after 24 and 48 h of
incubation (Figure 1A,B). … 48 h of incubation, respectively (Figure 4A,B). Taking into account …

[HTML][HTML] Pyrazole derivatives induce apoptosis via ROS generation in the triple negative breast cancer cells, MDA-MB-468

M Ashourpour, F Mostafavi-Hosseini… - Asian Pacific Journal …, 2021 - ncbi.nlm.nih.gov
… pertinent to the antitumor activity of Pyrazole derivatives does not exceed two decades,
the … Based on published data, Pyrazoles induce cytotoxicity to human cancer cells through …

Autophagy modulators in cancer therapy

K Buzun, A Gornowicz, R Lesyk, K Bielawski… - International Journal of …, 2021 - mdpi.com
… Intensive studies have revealed a whole range of novel compounds with an anticancer activity
that … Verteporfin is benzoporphyrin derivative consisting of two regioisomers (I and II). This …

Tanshinone IIA shows higher antiproliferative activities than Sinapic acid in 4 cancer cell lines and simultaneously induces apoptosis and necroptosis in human lung …

CY Lin, M Tam Ly, SH Yang, SC Lai… - Natural Product …, 2021 - journals.sagepub.com
antitumor activities of them were worth exploring, therefore, we examined their antitumor
activities … agents are naturally occurring compounds and their derivatives, 74% of which are …