… Nevertheless, catheter-ablation procedure based on isolation of the pulmonary veins was
superior to amiodarone for rhythm control in patients with paroxysmal or persistent AF and …

… that amiodarone and its metabolite (desethylamiodarone, DEA… human peripheral blood cells,
and one liver-derived human … against lung cell cytotoxicity [14]. Serviddio et al. showed that …

… Amiodarone is metabolized in the liver to desethylamiodarone [5]. During loading, it goes
through three … Pulmonary toxicity from amiodarone most commonly presents as interstitial …

… Desethylamiodarone is the primary metabolite which is electro physiologically … of cytotoxic
T cells in bronchoalveolar lavage fluid. Amiodarone treatment can lead to various pulmonary …

… to pulmonary fibrosis. Amiodarone has been shown to accumulate strongly in lung tissue, …
rat alveolar type II cells to show that amiodarone specifically accumulates in large amounts in …

… start to escape and resist therapy agents (cytotoxic drugs of chemotherapy and targeted
therapy) by … We used the pulmonary metastasis model that is widely used as an in-vivo test for …

… In this chapter, the discovery of the fact that amiodarone could inhibit this major metabolic …
that amiodarone can alter mitochondrial functions in other tissues such as the lung and …

… thyroiditis caused by amiodarone, desethylamiodarone as its … lung tests are recommended
initially when amiodarone is … the fact that amiodarone achieves most of its cytotoxic effect by …

… of pulmonary involvement following amiodarone assumption: asymptomatic lipid pneumonia
and APT. In turn APT can be caused by two possible mechanisms: a direct cytotoxic effect …

… Cell viability and cytotoxicity assays in primary human … and HL-1 cells.% cytotoxicity calculated
as the amount of lactate … HL-1 cells.% cytotoxicity expressed as the percentage of viable …