Modular DNA-origami-based nanoarrays enhance cell binding affinity through the “lock-and-key” interaction
M Mao, Z Lin, L Chen, Z Zou, J Zhang… - Journal of the …, 2023 - ACS Publications
… that DNA nanoarrays exhibit significantly enhanced target cell binding by increasing the
valency and adding specific auxiliary molecules. Finally, we used them for capturing CTCs to …
valency and adding specific auxiliary molecules. Finally, we used them for capturing CTCs to …
A topology-matching spike protein-capping tetrahedral DNA nanocrown for SARS-CoV-2 neutralization
J Chen, S Xu, Q Ye, H Chi, Y Li, M Wu, B Fan… - CCS …, 2023 - chinesechemsoc.org
… , one DNA nanocrown tends to interact with the NTD domains of a single S trimer rather
than several different S trimers on the surface of a virion providing that the number of DNA …
than several different S trimers on the surface of a virion providing that the number of DNA …
Programmable DNA framework sensors for in situ cell-surface pH analysis
… lipid membranes through hydrophobic interactions. Then, the three pendent DNA strands
of the TDF complementary to the chol-DNA were anchored on cell membrane via sequence-…
of the TDF complementary to the chol-DNA were anchored on cell membrane via sequence-…
Functionalized tetrahedral DNA frameworks for the capture of circulating tumor cells
… In this Protocol Update, we describe DNA-tetrahedral … DNA frameworks, termed ‘n-simplexes’,
can be used as probes to specifically target receptor−ligand interactions on the cell …
can be used as probes to specifically target receptor−ligand interactions on the cell …
Programming biomimetically confined aptamers with DNA frameworks
… effects of increased concentration of ligand, interaction between aptamers, water activity
inside the DNA framework, and electrostatics repulsion from the DNA framework, among others. …
inside the DNA framework, and electrostatics repulsion from the DNA framework, among others. …
T lymphocyte-captured DNA network for localized immunotherapy
C Yao, C Zhu, J Tang, J Ou, R Zhang… - Journal of the American …, 2021 - ACS Publications
… this DNA network can be extended to capture lymphocytes in … designed cell-capture network
made from DNA containing … of T lymphocytes (T-cells) and further localized immunotherapy. …
made from DNA containing … of T lymphocytes (T-cells) and further localized immunotherapy. …
[HTML][HTML] DNA-Programmed Biomolecular Spatial Pattern Recognition
Y Wang, L Ren, H Peng, L Guo, L Wang - Chemosensors, 2023 - mdpi.com
… interactions between proteins are also used to construct DNA–… (b) Snapshot HS-AFM
images of single IgGs captured by DNA … DNA origami and the total calcium signaling in B cells …
images of single IgGs captured by DNA … DNA origami and the total calcium signaling in B cells …
[HTML][HTML] Coating with flexible DNA network enhanced T-cell activation and tumor killing for adoptive cell therapy
Z Zhang, Q Liu, J Tan, X Zhan, T Liu, Y Wang… - … Pharmaceutica Sinica B, 2021 - Elsevier
… DNA network is constructed on cell surface by rolling circle amplification (RCA), and T cell-targeted
trivalent tetrahedral DNA … efficient and selective coating for T cells. The cytoprotective …
trivalent tetrahedral DNA … efficient and selective coating for T cells. The cytoprotective …
Programmable DNA Scaffolds Enable Orthogonal Engineering of Cell Membrane-Based Nanovesicles for Therapeutic Development
W Li, S Liu, Z Wang, L Gou, Y Ou, X Zhu, Y Zhou… - Nano Letters, 2024 - ACS Publications
… ligands are crucial for enhancing receptor–ligand binding and therapeutic effects, we have
rationally designed three DNA … with Chol-DNA through hydrophobic interactions is simple and …
rationally designed three DNA … with Chol-DNA through hydrophobic interactions is simple and …
Rationally designed multivalent aptamers targeting cell surface for biomedical applications
… to engage stable cell–cell interactions. Therefore, DNA nanotechnology can tune the interaction
of … orientation of multivalences for further improvement of capture efficiency. Fan’s group …
of … orientation of multivalences for further improvement of capture efficiency. Fan’s group …