Modular DNA-origami-based nanoarrays enhance cell binding affinity through the “lock-and-key” interaction

M Mao, Z Lin, L Chen, Z Zou, J Zhang… - Journal of the …, 2023 - ACS Publications
… that DNA nanoarrays exhibit significantly enhanced target cell binding by increasing the
valency and adding specific auxiliary molecules. Finally, we used them for capturing CTCs to …

A topology-matching spike protein-capping tetrahedral DNA nanocrown for SARS-CoV-2 neutralization

J Chen, S Xu, Q Ye, H Chi, Y Li, M Wu, B Fan… - CCS …, 2023 - chinesechemsoc.org
… , one DNA nanocrown tends to interact with the NTD domains of a single S trimer rather
than several different S trimers on the surface of a virion providing that the number of DNA

Programmable DNA framework sensors for in situ cell-surface pH analysis

J Liu, W Li, R Li, X Yin, S He, J Hu, S Ruan - Analytical Chemistry, 2021 - ACS Publications
… lipid membranes through hydrophobic interactions. Then, the three pendent DNA strands
of the TDF complementary to the chol-DNA were anchored on cell membrane via sequence-…

Functionalized tetrahedral DNA frameworks for the capture of circulating tumor cells

Y Chen, M Lin, D Ye, S Wang, X Zuo, M Li - Nature Protocols, 2024 - nature.com
… In this Protocol Update, we describe DNA-tetrahedral … DNA frameworks, termed ‘n-simplexes’,
can be used as probes to specifically target receptorligand interactions on the cell

Programming biomimetically confined aptamers with DNA frameworks

X Mao, M Liu, L Yan, M Deng, F Li, M Li, F Wang, J Li… - ACS …, 2020 - ACS Publications
… effects of increased concentration of ligand, interaction between aptamers, water activity
inside the DNA framework, and electrostatics repulsion from the DNA framework, among others. …

T lymphocyte-captured DNA network for localized immunotherapy

C Yao, C Zhu, J Tang, J Ou, R Zhang… - Journal of the American …, 2021 - ACS Publications
… this DNA network can be extended to capture lymphocytes in … designed cell-capture network
made from DNA containing … of T lymphocytes (T-cells) and further localized immunotherapy. …

[HTML][HTML] DNA-Programmed Biomolecular Spatial Pattern Recognition

Y Wang, L Ren, H Peng, L Guo, L Wang - Chemosensors, 2023 - mdpi.com
interactions between proteins are also used to construct DNA–… (b) Snapshot HS-AFM
images of single IgGs captured by DNADNA origami and the total calcium signaling in B cells

[HTML][HTML] Coating with flexible DNA network enhanced T-cell activation and tumor killing for adoptive cell therapy

Z Zhang, Q Liu, J Tan, X Zhan, T Liu, Y Wang… - … Pharmaceutica Sinica B, 2021 - Elsevier
DNA network is constructed on cell surface by rolling circle amplification (RCA), and T cell-targeted
trivalent tetrahedral DNA … efficient and selective coating for T cells. The cytoprotective …

Programmable DNA Scaffolds Enable Orthogonal Engineering of Cell Membrane-Based Nanovesicles for Therapeutic Development

W Li, S Liu, Z Wang, L Gou, Y Ou, X Zhu, Y Zhou… - Nano Letters, 2024 - ACS Publications
ligands are crucial for enhancing receptorligand binding and therapeutic effects, we have
rationally designed three DNA … with Chol-DNA through hydrophobic interactions is simple and …

Rationally designed multivalent aptamers targeting cell surface for biomedical applications

M Lin, J Zhang, H Wan, C Yan, F Xia - ACS Applied Materials & …, 2020 - ACS Publications
… to engage stable cellcell interactions. Therefore, DNA nanotechnology can tune the interaction
of … orientation of multivalences for further improvement of capture efficiency. Fan’s group …