Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development

M Yagi, M Kabata, A Tanaka, T Ukai, S Ohta… - Nature …, 2020 - nature.com
… In combination with genetic ablation of Dnmt3a or Dnmt3b, here we report unique de
novo DNA methylation target sites for both DNMT3 enzymes during embryonic development. …

[HTML][HTML] Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease

X Mei, J Blanchard, C Luellen, MJ Conboy… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
… This study shows that Elastic Net (EN) DNA methylation (DNAme) clocks have low accuracy
of … We found that change in methylation of cytosines with age is, interestingly, not the …

Analysis of DNA methylation profiles during sheep skeletal muscle development using whole-genome bisulfite sequencing

Y Fan, Y Liang, K Deng, Z Zhang, G Zhang, Y Zhang… - BMC genomics, 2020 - Springer
… To explore the functional importance of genome-scale DNA methylation during sheep … the
genome-wide DNA methylation profiles at key stages of Hu sheep developmental (fetus and …

Development of super-specific epigenome editing by targeted allele-specific DNA methylation

N Rajaram, AG Kouroukli, S Bens, P Bashtrykov… - Epigenetics & …, 2023 - Springer
… In this work, we aimed to apply the sgRNA/dCas9 unit for the development of a universal
ASEE system able to introduce allele-specific DNA methylation (ASM). Therefore, we …

DNA methylation changes during preimplantation development reveal inter-species differences and reprogramming events at imprinted genes

E Ivanova, S Canovas, S Garcia-Martínez, R Romar… - Clinical …, 2020 - Springer
… The results of this study detail the DNA methylation dynamics during the first week of
development in two major livestock species where this information was not previously available: …

[PDF][PDF] Developmental alterations in DNA methylation during gametogenesis from primordial germ cells to sperm

MB Maamar, D Beck, E Nilsson, JR McCarrey… - Iscience, 2022 - cell.com
developmental stage germ cells were isolated and analyzed for differential DNA methylation
… The most statistically significant DMRs were present at all stages of development and had …

[HTML][HTML] Prenatal methylmercury exposure and DNA methylation in seven-year-old children in the Seychelles Child Development Study

AC Ulloa, A Gliga, TM Love, D Pineda… - Environment …, 2021 - Elsevier
… MeHg exposure for DNA methylation of one GRIN2B CpG and two NR3C1 CpGs out of 12
total CpG sites. Higher prenatal MeHg was associated with higher methylation for each CpG …

DNA methylation at birth is associated with lung function development until age 26 years

N Mukherjee, R Arathimos, S Chen… - European …, 2021 - Eur Respiratory Soc
… utero conditions that mal-adapts the developing fetus to survive in postnatal environments, …
DNA methylation (DNAm) is an epigenetic marker that may retain memories of developmental

Epigenome-wide DNA methylation signature of benzo [a] pyrene exposure and their mediation roles in benzo [a] pyrene-associated lung cancer development

H Meng, G Li, W Wei, Y Bai, Y Feng, M Fu… - Journal of hazardous …, 2021 - Elsevier
… adducts and DNA methylations. Mediation analysis was applied to assess effect of DNA
methylation on … Our results highlight DNA methylation alterations as potential mediators in lung …

[HTML][HTML] Development and inter-laboratory validation of the VISAGE enhanced tool for age estimation from semen using quantitative DNA methylation analysis

A Heidegger, A Pisarek, M de la Puente… - Forensic Science …, 2022 - Elsevier
… Age prediction from semen requires different DNA methylation markers and the only assays
… of DNA methylation levels and sensitivity with DNA methylation controls. Furthermore, DNA