DNA methylation is a comprehensive marker for pediatric adrenocortical tumors
AC Bueno, RMP da Silva, MF Stecchini… - Endocrine-related …, 2022 - erc.bioscientifica.com
… In the present study, we aimed to analyze the DNA methylation profile of pACT samples
from a Brazilian cohort enriched with the Gp53-p.R337H mutation. We established two …
from a Brazilian cohort enriched with the Gp53-p.R337H mutation. We established two …
DNA methylation of steroidogenic enzymes in benign adrenocortical tumors: new insights in aldosterone-producing adenomas
G Di Dalmazi, L Morandi, B Rubin… - The Journal of …, 2020 - academic.oup.com
… DNA methylation of CYP11B1 seems not to be relevant in determining cortisol overproduction
in adrenal … in our study showed that adrenal incidentalomas and ACS were spread among …
in adrenal … in our study showed that adrenal incidentalomas and ACS were spread among …
Intratumor heterogeneity of prognostic DNA-based molecular markers in adrenocortical carcinoma
A Jouinot, J Lippert, M Fassnacht… - Endocrine …, 2020 - ec.bioscientifica.com
… markers measurable at the DNA level – somatic mutations, chromosome alteration profile
and targeted DNA methylation profile – by performing multiple measures for different tumor …
and targeted DNA methylation profile – by performing multiple measures for different tumor …
Past, present and future of epigenetics in adrenocortical carcinoma
M Ettaieb, T Kerkhofs, M van Engeland, H Haak - Cancers, 2020 - mdpi.com
… DNA methylation profiling has been suggested a reliable technique to distinguish between
benign and malignant adrenocortical … between benign and malignant adrenal tumors is of the …
benign and malignant adrenocortical … between benign and malignant adrenal tumors is of the …
HPA axis dysregulation is associated with differential methylation of CpG-sites in related genes
A Chatzittofis, ADE Boström, DM Ciuculete… - Scientific Reports, 2021 - nature.com
… DNA methylation shifts in Hypothalamic–pituitary–adrenal (… dysregulation, shifts in DNA
methylation of HPA axis related … Our findings revealed that DNA methylation shifts are involved …
methylation of HPA axis related … Our findings revealed that DNA methylation shifts are involved …
Alterations of DNA methylation were associated with the rapid growth of cortisol-producing adrenocortical adenoma during pregnancy
C Wang, Y Sun, X Yin, R Feng, R Feng, M Xu… - Clinical …, 2021 - Springer
… and examined the genome-wide DNA methylation profiles of non-pregnant and pregnant
patients with CPA. We aimed to identify the differences in DNA methylation signatures of non-…
patients with CPA. We aimed to identify the differences in DNA methylation signatures of non-…
Differential methylation pattern in pubertal girls associated with biochemical premature adrenarche
D Ponce, F Rodríguez, JP Miranda, AM Binder… - Epigenetics, 2023 - Taylor & Francis
… of the adrenal cortex (zona reticularis), leading to increased secretion of adrenal androgen
… PA, we selected 8 of the 31 DNA methylation markers for exploratory analysis of whether …
… PA, we selected 8 of the 31 DNA methylation markers for exploratory analysis of whether …
Identification of glucocorticoid-related molecular signature by whole blood methylome analysis
R Armignacco, A Jouinot, L Bouys… - European Journal of …, 2022 - academic.oup.com
… DNA methylation. Specifically, we analysed whole blood methylome in patients with
endogenous Cushing's syndrome, eucortisolism, or adrenal insufficiency, and we identified a …
endogenous Cushing's syndrome, eucortisolism, or adrenal insufficiency, and we identified a …
Epigenetic landscape of stress surfeit disorders: Key role for DNA methylation dynamics
… -adrenal (HPA) axis and stress-integrative brain structures. The main actors of the HPA axis
are the hypothalamus, pituitary, and adrenal … of glucocorticoids from the adrenal cortex. …
are the hypothalamus, pituitary, and adrenal … of glucocorticoids from the adrenal cortex. …
How to differentiate benign from malignant adrenocortical tumors?
CL Viëtor, SG Creemers, FJ van Kemenade… - Cancers, 2021 - mdpi.com
… Two prospective studies have shown that this imaging modality could identify adrenocortical
origin of local or metastatic adrenal tumors with a sensitivity of 38–83% and a specificity of …
origin of local or metastatic adrenal tumors with a sensitivity of 38–83% and a specificity of …