Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea

M Rojas-Pirela, D Andrade-Alviárez… - Open …, 2020 - royalsocietypublishing.org
… Apparently, the 3′-UTR of the PGK1 gene contains a … Peptide mapping and site-directed
mutagenesis studies … capacity, improved ability to repair DNA damage and an upregulation of …

Regulation of the base excision DNA repair pathway is critical for proper cell function

AJ McPherson-Davie - 2020 - search.proquest.com
… , a base excision DNA repair protein, reveals novel genetic … we mapped the specific sites of
SUMO modification within Ntg1 … Estimates suggest that 90,000 oxidative lesions and 200,000 …

[HTML][HTML] Mechanisms of UV-induced mutations and skin cancer

GP Pfeifer - Genome instability & disease, 2020 - Springer
… causes various types of DNA damage, which leads to … of resolution, the focus of these UV
damage mapping studies … Although still associated with high sequencing costs, there are now …

[HTML][HTML] Damage mapping techniques and the light they have shed on canonical and atypical UV photoproducts

KA Bohm, JJ Wyrick - Frontiers in Genetics, 2023 - frontiersin.org
… in the promoter region of the PGK1 gene in UV-irradiated cells. A … The resolution of DNA
damage mapping methods was … high-resolution (ie, single nucleotide resolution) mapping of …

[HTML][HTML] Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells

S Ferrari, A Jacob, D Cesana, M Laugel, S Beretta… - Cell Stem Cell, 2022 - cell.com
… Long-range gene editing by homology-directed repair (HDR) … trigger sustained p53-mediated
DNA damage response (DDR) … a detrimental p53-mediated DNA damage response (DDR) …

[HTML][HTML] … cancer increased transcription of oxidative phosphorylation genes and diverted glycolysis to boost S-glutathionylation in lymphatic intravascular metastatic …

D Martinez-Marin, RA Helmer, G Kaur, RL Washburn… - Plos one, 2023 - journals.plos.org
… from DNA damage at a transcriptomic level induction of DNA … species-specific mapping
unambiguously differentiated gene … As the first ATP generating enzyme in glycolysis, PGK1

Two independent DNA repair pathways cause mutagenesis in template switching deficient Saccharomyces cerevisiae

YK Jiang, EA Medley, GW Brown - Genetics, 2023 - academic.oup.com
Pgk1 was detected with an anti-Pgk1 mouse antibody (Invitrogen … We used genetic approaches
to define 2 mutagenic repair … both mutagenic repair pathways contribute to mutation rate

[HTML][HTML] ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesterase

N babu Chinnam, R Thapar, AS Arvai… - Journal of Biological …, 2024 - ASBMB
… 29 and 3 mutations, and genetic instability markers. We … and Human (Hs) PDE domain
revealing high-resolution … for nucleic acid alkylation damage reversal in DNA damage responses (…

Protein-DNA Interactions: A Technical Overview

G Ticli, O Cazzalini, E Prosperi - Handbook of Molecular Biotechnology - taylorfrancis.com
… during DNA replication, recombination, and DNA repair) help … to map DSBs at nucleotide
resolution named BLESS (direct … somal DNA at the CpG island and promoter of human PGK1. …

Molecular mechanism of glycolytic flux control intrinsic to human phosphoglycerate kinase

H Yagi, T Kasai, E Rioual, T Ikeya… - Proceedings of the …, 2021 - National Acad Sciences
… (A) Mapping of isoleucine residues on the structure of hPGK (Protein Data Bank [PDB] code:
… and resulted in a slowdown in its turnover rate (steps 4′ through 6). Indeed, the k off value …