… Molecular dynamics simulations and stopped-flow Förster … Coiled-coils (CC) are a
frequent suprastructural element, … Since CC-forming peptides are positioned at varying intra-…

… The design of small molecules and molecular assemblies with … and conformations for even
a modestly long protein … , but was serendipitously found to crystallize as a four helix coiled-coil …

… parallel assemblies to antiparallel conformations. For example, … Equilibrium and
variable-temperature CD spectra revealed … to introduce cavities, small-molecule-binding pockets, …

… , de novo sequences of orthogonally interacting coiled-coil … 4 The limit in the quality of SAXS
fitting while varying the number … These two models are in a similar conformation with a small …

… conformations occur less commonly in natural proteins. Indeed… Furthermore, by analogy with
their use in designed coiled-coil … in sequence leading to varying degrees of oligomerization. …

… of the interaction strength by varying their sequence and lengths … We leveraged the molecular
level detail provided in the … Aiming to design single-component condensates, we used two …

… (A) Representative CD spectra at 5 C and (B) variable … (1) Examples of this include
conformational changes in … switchable PPIs permit high-speed molecular signaling that does not …

… systems, imparting a novel way to change the conformation … As an example of how variable
libraries can be used to … Their work took a helix that can spontaneously form into a coiled coil …

… have succeeded without his molecular biology Midas touch! I … the design of a wide range of
de novo coiled-coil structures. (… of larger proteins, for which conformational updates involve a …

… molecular self-assembly. Here we characterize a new two subunit system composed of the
SasG rod protein genetically conjugated with de novo designed … of varying lengths featuring …