… -deficient O-glycans in its hinge region (galactose-deficient IgA1… This scenario is further
supported by the results of experiments … that are responsible for promoting the migration of these …

… with IgA nephropathy are enriched for galactose-deficient IgA1 … These experimental
approaches demonstrate the key roles … in the formation of nephritogenic immune complexes. …

… in people without significant glycosylation defects, as long as … model of gluten-induced
experimental IgA glomerulopathy. … B cells are involved in nephritogenic IgA synthesis in a T-cell-…

… Moreover, nephritogenic IgA and its related immune … -specific IgA has been investigated
with some experimental models … in autoimmune states, inducing a defect in the regulation of B…

… particularly the characteristics of nephritogenic IgA. Herein, we … from IgAN patients are
enriched with these galactose-deficient … demonstrated; both in vitro and in vivo experiments have …

… Genome-wide association studies and experimental models have … The galactose-deficient
hinge region with terminally exposed … These “nephritogenic” immune complexes may activate …

… to induce an increase of serum BAFF and galactose deficient-… All experiments were performed
in accordance with French … mice (22), confirming that nephritogenic IgA is modulated by a …

… These complexes are formed by galactose-deficient (Gd) IgA1 with … Fecal microbiota
transplantation (FMT) experiments in mice … To assess characteristics of nephritogenic IgA and …

… Autoantibodies specifically recognize galactose-deficient … Before the ‘70s, only IgG was
considered a nephritogenic … Experimental data showed that fructose caused hypertrophy of …

… aspects through the use of experimental models. Small-animal … The nephritogenic potential
of hypogalactosylated IgA was … defect of IgA is not the sole cause and is not a prerequisite for …