Melatonin protects against chronic stress-induced oxidative meiotic defects in mice MII oocytes by regulating SIRT1

Y Guo, J Sun, S Bu, B Li, Q Zhang, Q Wang, D Lai - Cell Cycle, 2020 - Taylor & Francis
… In addition, the deficit of mitochondria-derived ATP during oxidative stress impairs mouse
oocyte spindles [Citation35]. SIRT1 is also a regulator of ROS homeostasis [Citation13] and the …

Oxidative stress induces meiotic defects of oocytes in a mouse psoriasis model

ZQ Zhang, SB Tang, YY Jiang, FY Long, F He… - Cell Death & …, 2022 - nature.com
… We discover that oocytes from psoriasis-like mice display spindle/… -like mice show peroxidation
and this peroxidation affects the … Ψm was the driving force for the synthesis of ATP. Red …

Triclocarban exposure affects mouse oocyte in vitro maturation through inducing mitochondrial dysfunction and oxidative stress

ZM Ding, MJ Ahmad, F Meng, F Chen, YS Wang… - Environmental …, 2020 - Elsevier
oocytes experienced MII stage, while most of TCC-treated … TCC treated oocytes, suggesting
any disruption at spindle structure and/… reducing ATP content, which further disrupted oocyte

The role of mitochondria in oocyte maturation

A Kirillova, JEJ Smitz, GT Sukhikh, I Mazunin - Cells, 2021 - mdpi.com
… microtubules are assembled from the opposite spindle poles … most likely is not severely
impaired due to in vitro conditions. … Oxidative stress can severely harm the oocyte’s function by …

Mitochondrial activity and redox status in oocytes from old mice: the interplay between maternal and postovulatory aging

K Czajkowska, A Ajduk - Theriogenology, 2023 - Elsevier
MII oocytes isolated from mice in advanced reproductive age. (A) A representative image of
MII oocytes … Indeed, it has been shown that the genetic background of mice affects oocytes

Toxicant effects on mammalian oocyte mitochondria

KF Malott, U Luderer - Biology of Reproduction, 2021 - academic.oup.com
spindle assembly and chromosome alignment, two ATP-… MXC and rotenone induce ovarian
oxidative damage [91, 94], … and that glyphosate hinders the ability of the oocyte to effectively …

Human ovarian aging is characterized by oxidative damage and mitochondrial dysfunction

MAJ Smits, BV Schomakers, M van Weeghel… - Human …, 2023 - academic.oup.com
… large decreases in mitochondria-derived substrates and end … by protecting the meiotic
spindle against oxidative stress, but … or correcting glutathione deficiency in oocytes of advanced …

The role of mitochondrial dynamics in oocyte and early embryo development

RM Yildirim, E Seli - Seminars in Cell & Developmental Biology, 2024 - Elsevier
… As such, mitochondria derived from the oocyte serve as a … in mouse oocytes, the outcomes
showed significant spindle … safeguard mitochondria from oxidative damage and enhance their …

Oocyte mitochondria—Key regulators of oocyte function and potential therapeutic targets for improving fertility

D Adhikari, I Lee, WS Yuen, J Carroll - Biology of Reproduction, 2022 - academic.oup.com
… with energy deficiency and oxidative stress. Pharmacological … More recently, the role of
mitochondria-derived metabolites in … -15) during in vitro maturation protects against spindle and …

Melatonin protects against Mdivi-1-induced abnormal spindle assembly and mitochondrial superoxide production during porcine oocyte maturation

SG Yang, SY Joe, JW Bae, GD Heo, HJ Park… - Frontiers in cell and …, 2021 - frontiersin.org
… -1 promotes the deficiency of spindle assembly by disturbing … suppresses oxidative
stress and restores abnormal spindlespindle assembly dynamics, and mitochondria-derived