Structural and biochemical characteristics of mRNA nanoparticles determine anti–SARS-CoV-2 humoral and cellular immune responses

Y Shi, J Huang, Y Liu, J Liu, X Guo, J Li, L Gong… - Science …, 2022 - science.org
major histocompatibility complex (MHC) class IIrestricted presentation that activated specific
CD4 + T cells and B cells … suggests that ADE promotes viral infections via immune complex

Immune cell interactions in tuberculosis

JAL Flynn, J Chan - Cell, 2022 - cell.com
… Monocytes, macrophages, neutrophils, and dendritic cells are … There is no doubt that CD4
T cells are a key factor in the … of immune complex (IC) by DC to augment T cell responses, (…

Autoantigens in rheumatoid arthritis and the potential for antigen-specific tolerising immunotherapy

HJ Nel, V Malmström, DC Wraith… - The Lancet …, 2020 - thelancet.com
immune complex formation and macrophage or dendritic cell … or particulate formulation that
ensures uptake and antigen … present MHC class II-restricted peptides to CD4 + T cells and …

[HTML][HTML] A multiscale mechanistic model of human dendritic cells for in-silico investigation of immune responses and novel therapeutics discovery

SS Aghamiri, BL Puniya, R Amin, T Helikar - Frontiers in Immunology, 2023 - frontiersin.org
Dendritic cells, but not macrophages or b cells, activate major histocompatibility complex
class II-restricted CD4+ T cells upon immune-complex uptake. …

The incorporation of cationic property and immunopotentiator in poly (lactic acid) microparticles promoted the immune response against chronic hepatitis B

T Lu, F Hu, H Yue, T Yang, G Ma - Journal of controlled release, 2020 - Elsevier
… the APCs uptake, thus arousing dendritic cells (DCs) activation. The … -D group produced
higher frequency of T cm in CD4 + T cells … immune cells like DCs, macrophages. It was proven …

… of chimeric antigen receptor activation by the extracellular domain: experience with single domain antibodies targeting multiple myeloma cells highlights the need for …

H Hanssens, F Meeus, Y De Vlaeminck… - Frontiers in …, 2024 - frontiersin.org
… and macrophages) and absent on hematopoietic stem cells (… designed CARs in a highly
immune-complex disease such as MM, … As such, the ideal composition of CD4 + /CD8 + T-cell

Innocent until proven guilty: IgA and inflammatory diseases

AV Bos - 2024 - research.vu.nl
… , which are subsequently presented on MHC-II to CD4 T cells [7]. … , eosinophils, macrophages
and subsets of dendritic cells [32-… factor and immune complex formation by AECA [80, 94]. …

The Cells of the Immune System

A Maldonado Cerda, CM Garcia, CS Foster - Albert and Jakobiec's …, 2021 - Springer
… responses in the absence of MHC class II-restricted T-cell help [8]. … B cells are essential for
optimal CD4+ T-cell activation during … , after endothelial injury resulting from immune complex

Characterization and root cause analysis of immunogenicity to pasotuxizumab (AMG 212), a prostate-specific membrane antigen-targeting bispecific T-cell engager …

…, W Loidl, C Grüllich, T Eggert, B Tran… - Frontiers in …, 2023 - frontiersin.org
… consisting of 35 MHC class II-restricted peptides from human … any association with
immune-complex related safety events … cycle 1, we assessed peripheral CD4+ T cell activation at …

[PDF][PDF] This work was Published in the Journal of Immunology Research 2016

E Breman, JM Ruben… - the quest to monitor …, 2020 - repository.uantwerpen.be
… to mediate antigen uptake and presentation via HLA class II to CD4 T-… As the immune-complex
is taken-up, it is possible thatuptake of antigens strongly enhances HLA class IIrestricted