… this chimeric strategy is that which was developed from a DNA vaccine encoding the Env
protein of HIV-1 together with plasmids … DCs have limited lysosomal capacity due to decreased …

… cells with HIV vector (∆RI/∆E/Gluc), HIV packaging plasmid (Δ8… against other HIV components,
such as HIV Gag. Overall, the … Cathepsins active within the cellular endosomal/lysosomal …

… of the Lysosome-associated membrane protein-1 (LAMP-1) … to engineer T-cells with chimeric
antigen receptor genes in … HEK 293T cells with the retroviral vector and Peq-Pam plasmid (…

… with lysosomal-associated membrane protein 1 (LAMP-1) … follicular dendritic cells (FDCs), a
reduction of T FH cells, and a … encoding either LAMP/Gag or Gag plasmids. We immunized 7-…

… HIV Gag polyprotein (Gag-Pro-Pol) [199, 200]. Upon proteolytic cleavage of this precursor,
the mature HIV-Gag … endosomes, lysosomes, and antigen-processing vesicles[220]. Instead, …

… CD8 T cells or those expressing chimeric antigen receptors (… T cells are well established
to be prime target cells for HIV … alpha activates human immunodeficiency virus type 1 through …

… Lysosomal-associated membrane protein 1 LAT1 … ) was later identified as human
immunodeficiency virus type 1 (HIV-1) … by antigen presenting cells (APCs) such as dendritic cells …

… chimera plasmid pVax1 vector vaccine construct (both the construct and the original pVax1
(parent plasmid without Gag) … HIV-1 p55-gag gene DNA. It encodes a secreted form of the …

… recombinant LAMP1 within chimeric EBOV GP and targets the lysosome. The … 1B) stored
in our laboratory was previously constructed based on plasmid p43-LAMP, and the plasmid …

… Env protein and Envcontaining virions to lysosomes. When … rescued Env expression in
HIV1-infected macrophages lacking … Macrophages, along with dendritic cells and B cells, degrade …