… pain. J Orthop Sports Phys Ther 2024;54(3):155-160. doi:10.2519/jospt.2024.12113 In this
editorial, we explain how descending modulation of pain is … the descending pain modulatory …

… It may be argued that if the endogenous descending modulation of pain exerts a tonic
action, its physiological significance can be compared with other neural systems that in a tonic …

… assessing descending pain modulation in humans and animals are conditioned pain modulation
(… In CPM paradigms, this “pain-inhibits-pain” effect is assessed via the modulation of the …

… the descending modulation in the DH, thereby providing analgesia. As the main neurotransmitter
involved in descending modulation of … focuses on serotonergic descending projections. …

… study were to examine the association of pain sensitization (ie, ascending facilitation) and
descending pain modulation to ICOAP-defined pain patterns and the unpredictability of pain. …

… Overall, our results provided evidence suggesting deficits in ascending and descending
pain modulation pathways, which were highly associated with the intensity of chronic pain and …

… context-specific changes in descending pain modulation. … , we compared the RIII reflex
modulation elicited by four standardized … Our working hypothesis was that descending modulation …

… descending pain inhibition, an increase in descending pain facilitation, or both. Alterations to
descending modulation … in the pathophysiology of chronic pain in multiple clinical conditions…

… descending from the brain via the brainstem to the spinal cord (Heinricher et al., 2009).
These descending and endogenous pain … pain experience. Understanding how this system of …

… , with a focus on identifying the roles of specific cell types involved in descending modulation…
models for descending modulation and explores the roles of the descending modulatory …