… Desmoplasia and hypoxia play critical roles in chemotherapy resistance in pancreatic
cancer, prompting research into their mechanisms and the development of innovative drug …

… mechanisms of chemoresistance in pancreatic cancer with a … the desmoplastic reaction in
combination with chemotherapy … than chemotherapy alone, thus highlighting desmoplasia as …

… in combination with chemotherapy [7]. Similarly, direct targeting of collagen with
collagenase-loaded nanoparticles has also been shown to increase efficacy of chemotherapy …

… of pancreatic cancer. Inadequate blood supply and desmoplasia in the microenvironment
of pancreatic cancer … In summary, in pancreatic cancers, low blood supply and desmoplasia …

… of the desmoplastic pancreatic tumor stroma in combination with chemotherapy, targeted
therapy, or immunotherapy would be an appealing option for pancreatic cancer treatment. In …

… desmoplastic stroma that is resistant to chemotherapy and radiotherapy and limits treatment
effectiveness.Single- cell RNA sequencing of pancreatic cancer … that desmoplastic reaction …

… a role in pancreatic cancer chemotherapy resistance because … stiffness in hepatocellular
carcinoma chemoresistance and in … , which induce tumor cell chemoresistance through multiple …

… analyses of pancreatic cancer stroma have also … pancreatic cancer stromal biology and
discusses treatment opportunities of stroma-modifying therapies against this hard-to-treat cancer…

… The five-year survival rate for metastatic pancreatic cancer is currently only … pancreatic
cancer formation and progression. We asked if mebendazole could prevent initiation of pancreatic …

… desmoplastic reaction in PDAC and opens the way for new therapeutic approaches to
overcome the chemoresistance … Undifferentiated pancreatic cancer without a desmoplastic …