Kinetochore life histories reveal the origins of chromosome mis-segregation and correction mechanisms
… We also show that Aurora B operates during early anaphase to promote … associates with
disrupted metaphase oscillations, which would be consistent with these merotelic kinetochores …
disrupted metaphase oscillations, which would be consistent with these merotelic kinetochores …
Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis
SR Wellard, K Schindler… - Journal of cell science, 2020 - journals.biologists.com
… In future work, identification of AURKB/C targets during spermatogenesis will improve our
understanding of the meiotic functions Aurora kinases play during gametogenesis. …
understanding of the meiotic functions Aurora kinases play during gametogenesis. …
Prolonged metaphase II arrest weakens Aurora B/C-dependent error correction in mouse oocytes
A Langeoire, A Kem-Seng, D Cladiere, K Wassmann… - bioRxiv, 2023 - biorxiv.org
… Even though this co-orientation of sister kinetochores may … (correct (bipolar) or incorrect,
such as monopolar or merotelic) … of tension can be detected efficiently by Aurora B/C and can …
such as monopolar or merotelic) … of tension can be detected efficiently by Aurora B/C and can …
[HTML][HTML] The deubiquitinating enzyme complex BRISC regulates Aurora B activation via lysine-63-linked ubiquitination in mitosis
Q Li, Y Ma, F Chang, Y Xu, J Deng, J Duan… - Communications …, 2022 - nature.com
… requires bi-oriented kinetochore-microtubule attachment on … detected in the immunoprecipitates
of endogenous Aurora B … of merotelic attachments, a single kinetochore attaches to …
of endogenous Aurora B … of merotelic attachments, a single kinetochore attaches to …
Prometaphase
LT Ferreira, H Maiato - Seminars in Cell & Developmental Biology, 2021 - Elsevier
… are corrected, become long-lived and stable, and Aurora B kinase … The CPC associates with
chromosomes in early mitosis and … attachments, merotelic attachments are bi-oriented and …
chromosomes in early mitosis and … attachments, merotelic attachments are bi-oriented and …
Aurora B and condensin are dispensable for chromosome arm and telomere separation during meiosis II
J Berthezene, C Reyes, T Li, S Coulon… - … Biology of the Cell, 2020 - Am Soc Cell Biol
… Yet, the role of Aurora in correction of merotelic attachment is only partially dependent on …
Conversely and similarly to our observations in mitosis, we were able to detect a subfraction …
Conversely and similarly to our observations in mitosis, we were able to detect a subfraction …
[HTML][HTML] The role of mitotic kinases and the RZZ Complex in kinetochore-microtubule attachments: doing the right link
… interface and discuss how AURORA B and PLK1 coordinate … a merotelic KT still segregate
to the correct spindle pole. The … (A) AURORA B kinase associates with INCENP, BOREALIN …
to the correct spindle pole. The … (A) AURORA B kinase associates with INCENP, BOREALIN …
Principles and dynamics of spindle assembly checkpoint signalling
AD McAinsh, GJPL Kops - Nature Reviews Molecular Cell Biology, 2023 - nature.com
… mal-oriented attachments are corrected through Aurora B-… of merotelic attachment may involve
Aurora B-dependent error … Binding partners of key domains are indicated and amino acids …
Aurora B-dependent error … Binding partners of key domains are indicated and amino acids …
[HTML][HTML] Aneuploidy in cancer: lessons from acute lymphoblastic leukemia
… , and Cdc20) at unattached kinetochores and keep the spindle … Correct kinetochore–microtubule
attachments inactivate the … Merotelic attachments are usually not sensed by aurora B, …
attachments inactivate the … Merotelic attachments are usually not sensed by aurora B, …
Aurora B activity is promoted by cooperation between discrete localization sites in budding yeast
T Marsoner, P Yedavalli, C Masnovo… - … Biology of the Cell, 2022 - Am Soc Cell Biol
… To detect Ipl1 phosphorylation of the kinetochore, we generated a phosphospecific antibody
that recognizes phosphorylated serine 37 on Ndc80 and measured the signal by western …
that recognizes phosphorylated serine 37 on Ndc80 and measured the signal by western …